Journal article
Finding MEMO-Emerging Evidence for MEMO1 ' s Function in Development and Disease
Genes, Vol.11(11), pp.1-22
11/01/2020
DOI: 10.3390/genes11111316
PMCID: PMC7694686
PMID: 33172038
Abstract
Although conserved throughout animal kingdoms, the protein encoded by the gene Mediator of ERBB2 Driven Cell Motility 1 or MEMO1, has only recently come into focus. True to its namesake, MEMO1 first emerged from a proteomic screen of molecules bound to the ERBB2 receptor and was found to be necessary for efficient cell migration upon receptor activation. While initially placed within the context of breast cancer metastasis-a pathological state that has provided tremendous insight into MEMO1 ' s cellular roles-MEMO1 ' s function has since expanded to encompass additional cancer cell types, developmental processes during embryogenesis and homeostatic regulation of adult organ systems. Owing to MEMO1 ' s deep conservation, a variety of model organisms have been amenable to uncovering biological facets of this multipurpose protein; facets ranging from the cellular (e.g., receptor signaling, cytoskeletal regulation, redox flux) to the organismal (e.g., mineralization and mineral homeostasis, neuro/gliogenesis, vasculogenesis) level. Although these facets emerge at the intersection of numerous biological and human disease processes, how and if they are interconnected remains to be resolved. Here, we review our current understanding of this 'enigmatic' molecule, its role in development and disease and open questions emerging from these previous studies.
Details
- Title: Subtitle
- Finding MEMO-Emerging Evidence for MEMO1 ' s Function in Development and Disease
- Creators
- Michaela D. Schotanus - University of IowaEric Van Otterloo - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Genes, Vol.11(11), pp.1-22
- DOI
- 10.3390/genes11111316
- PMID
- 33172038
- PMCID
- PMC7694686
- NLM abbreviation
- Genes (Basel)
- ISSN
- 2073-4425
- eISSN
- 2073-4425
- Publisher
- Mdpi
- Number of pages
- 22
- Grant note
- R00DE026823 / National Institute of Dental and Craniofacial Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) University of Iowa, College of Dentistry
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Anatomy and Cell Biology; Craniofacial Anomalies Research Center; Dental Research; Periodontics
- Record Identifier
- 9984284341702771
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