Journal article
Findings from the National Birth Defects Prevention Study: Interpretation and translation for the clinician: Interpreting Findings from the NBDPS
Birth defects research. A Clinical and molecular teratology, Vol.103(8), pp.721-728
08/2015
DOI: 10.1002/bdra.23394
PMID: 26109026
Abstract
Background
The National Birth Defects Prevention Study (NBDPS) is a large U.S. multi-site case–control study first established in 1996 to identify potentially preventable environmental causes and genetic risk factors for more than 30 selected categories of major birth defects.
Methods
Numerous reports with both positive and negative findings have been produced by the NBDPS, and many have influenced clinical practice. Many NBDPS reports have included novel findings, and in some cases these findings could only be considered hypothesis-generating. Other reports have met criteria for causality such as replication of findings in other studies, biological plausibility, and coherence.
Results
However, translation of even strongly supported associations, in some cases, has required clinicians to learn to communicate information to patients about small and uncertain absolute risks in the context of the potential effects of under- or poorly treated maternal conditions.
Conclusion
The NBDPS has continued to play an important role as a rich U.S. data source that can advance the understanding of maternal conditions and their treatments in relation to birth defects.
Details
- Title: Subtitle
- Findings from the National Birth Defects Prevention Study: Interpretation and translation for the clinician: Interpreting Findings from the NBDPS
- Creators
- Sura Alwan - Department of Medical Genetics; University of British Columbia; Vancouver BC CanadaChristina D Chambers - Department of Pediatrics; University of California; San Diego La Jolla California, Department of Family Medicine and Public Health; University of California; San Diego La Jolla CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.103(8), pp.721-728
- DOI
- 10.1002/bdra.23394
- PMID
- 26109026
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214685602771
Metrics
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