Fine mapping of the usher syndrome type IC to chromosome 11p14 and identification of flanking markers by haplotype analysis

R Ayyagari; Y Li; R J Smith; M Z Pelias; J F Hejtmancik

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Fine mapping of the usher syndrome type IC to chromosome 11p14 and identification of flanking markers by haplotype analysis

Journal article

Open access

Peer reviewed

Fine mapping of the usher syndrome type IC to chromosome 11p14 and identification of flanking markers by haplotype analysis

R Ayyagari, Y Li, R J Smith, M Z Pelias and J F Hejtmancik

Molecular vision, Vol.1, 2

10/25/1995

PMID: 9238080

Appears in Diamond Open Access

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http://www.molvis.org/molvis/v1/a4/View

Published (Version of record) Open Access

Abstract

To refine the map position of the Usher syndrome type 1C (USH1C) locus to 11p14-p15.1 in the French-Acadian population settled in Louisiana. Linkage and haplotype analysis of Ush1C in the French-Acadian families from southwestern Louisiana was carried out using additional markers known to map to the USH1C interval. Markers localized to 11p were also mapped on the J1 somatic cell hybrid panel. This analysis also helped to localize precisely the USH1C interval. New flanking markers for USH1C have been identified, localizing the USH1C gene to a 1 cM interval between markers D11S1397 and D11S1888. Markers D11S1890 and D11S1888 were placed within the USH1C interval. Analysis of all the markers in the USH1C region flanked by D11S1397 and D11S1888 on the J1 somatic cell hybrid panel localized USH1C to the upper half of chromosome 11p14. The Usher Syndrome type 1C gene has been localized to a 1 cM interval between the markers D11S1397 and D11S1888 on chromosome 11p14.

Haplotypes

France - ethnology

Canada - ethnology

Humans

Louisiana

Retinitis Pigmentosa - genetics

Chromosome Mapping

Chromosomes, Human, Pair 11

Hearing Loss, Sensorineural - genetics

Syndrome

Microsatellite Repeats - genetics

Details

Title: Subtitle: Fine mapping of the usher syndrome type IC to chromosome 11p14 and identification of flanking markers by haplotype analysis
Creators: R Ayyagari - National Eye Institute, National Institutes of Health, Bethesda, MD, USA
Y Li
R J Smith
M Z Pelias
J F Hejtmancik
Resource Type: Journal article
Publication Details: Molecular vision, Vol.1, 2
PMID: 9238080
NLM abbreviation: Mol Vis
eISSN: 1090-0535
Publisher: United States
Language: English
Date published: 10/25/1995
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
Record Identifier: 9984006305302771

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