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First Description of Klebsiella pneumoniae Harboring CTX-M β-Lactamases (CTX-M-14 and CTX-M-3) in Taiwan
Journal article   Open access   Peer reviewed

First Description of Klebsiella pneumoniae Harboring CTX-M β-Lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Wen Liang Yu, Patricia L Winokur, Diana L Von Stein, Michael A Pfaller, Jen Hsien Wang and Ronald N Jones
Antimicrobial agents and chemotherapy, Vol.46(4), pp.1098-1100
04/2002
DOI: 10.1128/AAC.46.4.1098-1100.2002
PMCID: PMC127095
PMID: 11897596
url
https://doi.org/10.1128/AAC.46.4.1098-1100.2002View
Published (Version of record) Open Access

Abstract

Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. β-Lactamases with pIs of 7.9 ( n = 22) and 8.4 ( n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the β-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.
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