Journal article
First Exons and Introns – A Survey of GC Content and Gene Structure in the Human Genome
In silico biology, Vol.6(3), pp.237-242
2006
PMID: 16922687
Abstract
Most transcriptional regulatory elements are located in non-coding DNA. In particular, some first introns play a vital role in transcriptional control and splicing. The length and GC-content of first exons and introns in complex organisms suggests that these structural units are likely to be important functional elements in large genomes. Hence, in this paper we perform a systematic comparison of exon-intron structure and GC content on all known genes in the human genome. Our in-silico analysis found that the GC content of introns and exons varies significantly depending on their length. On average, the first intron of a gene is significantly longer than other introns in the same gene. Our results also show that first introns and exons are more GC rich than last and internal. This study provides insight into the structure of eukaryotic genes. These results confirm and expand the previously identified regulatory potential of first exons and introns.
Details
- Title: Subtitle
- First Exons and Introns – A Survey of GC Content and Gene Structure in the Human Genome
- Creators
- Krishna R Kalari - Center for Bioinformatics and Computational Biology, The University of Iowa, Iowa City, IA 52242, USAMelanie CasavantThomas B BairHenry L KeenJosep M ComeronThomas L CasavantTodd E Scheetz
- Resource Type
- Journal article
- Publication Details
- In silico biology, Vol.6(3), pp.237-242
- Publisher
- Netherlands
- PMID
- 16922687
- ISSN
- 1386-6338
- eISSN
- 1434-3207
- Grant note
- 1F32HG002881 / NHGRI NIH HHS
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Biology; Ophthalmology and Visual Sciences; Iowa Institute of Human Genetics
- Record Identifier
- 9983979902102771
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