Journal article
First Prize: Characterization of Renal Ischemia Using DLP® Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion
Journal of endourology, Vol.24(3), pp.321-325
03/2010
DOI: 10.1089/end.2009.0184
PMID: 20180629
Abstract
Background and Purpose: Renal artery-only (AO) occlusion, as opposed to artery and vein (AV) occlusion, has demonstrated some benefit in reducing renal insufficiency during warm ischemia. In this pilot study, we used digital light projection hyperspectral imaging (HSI) to construct a “real time” tissue oxygenation “map” to determine whether there are differences in renal tissue oxygenation during vascular occlusion with AO vs AV.
Materials and Methods: Renal vascular occlusion with either AO or AV was performed for 60 minutes in seven porcine renal units. Using HSI, the percentage of oxyhemoglobin (%HbO2) in the renal cortex was determined at 4-minute increments throughout the ischemic period and for 30 minutes after reperfusion.
Results: Average baseline %HbO2 in all animals was approximately 70%. After vascular occlusion in both cohorts, %HbO2 decreased by one third within 2 to 5 minutes, with a gradual decline in %HbO2 over the remaining 55 minutes. Oxyhemoglobin profiles for AO and AV occlusion diverged significantly between 16 and 24 minutes after vascular occlusion (P = 0.0001 and 0.036, respectively), with a merging of the two curves occurring after approximately 36 minutes (P = 0.093). During reperfusion, average %HbO2 improved to 72.4% after 25 to 30 minutes.
Conclusion: In this pilot study, we demonstrate that renal tissue oxygenation drops rapidly after occlusion of the renal vasculature and returns to near baseline 30 minutes after reperfusion. In the porcine model, the %HbO2 differs significantly between AO and AV occlusion for up to 35 minutes after ischemia onset, indicating a possible “ischemic window” in which AO occlusion may provide benefit over AV occlusion.
Details
- Title: Subtitle
- First Prize: Characterization of Renal Ischemia Using DLP® Hyperspectral Imaging: A Pilot Study Comparing Artery-Only Occlusion Versus Artery and Vein Occlusion
- Creators
- Chad R Tracy - University of Iowa Hospitals and Clinics, Iowa City, IowaJohn D Terrell - University of Iowa Hospitals and Clinics, Iowa City, IowaRobert P Francis - University of Texas at Arlington, Arlington, TexasEleanor F Wehner - University of Texas at Arlington, Arlington, TexasJack Smith - Texas Instruments, Dallas, TexasMaritoni Litorja - National Institute of Standards and Technology, Gaithersburg, MarylandDoyle L Hawkins - University of Texas at Arlington, Arlington, TexasMargaret S Pearle - University of Iowa Hospitals and Clinics, Iowa City, IowaJeffrey A Cadeddu - University of Iowa Hospitals and Clinics, Iowa City, IowaKarel J Zuzak - University of Texas at Arlington, Arlington, Texas
- Resource Type
- Journal article
- Publication Details
- Journal of endourology, Vol.24(3), pp.321-325
- DOI
- 10.1089/end.2009.0184
- PMID
- 20180629
- ISSN
- 0892-7790
- eISSN
- 1557-900X
- Language
- English
- Date published
- 03/2010
- Academic Unit
- Radiology; Urology
- Record Identifier
- 9984051514002771
Metrics
11 Record Views