First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report

Kyle A. Merrill; Kelli A. Krallman; Daniel Loeb; Stephen W. Standage; Dawn Mattoon; Dandan Shan; Stuart L. Goldstein; Meredith P. Schuh

doi:10.1159/000527290

Back

First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report

Journal article

Open access

Peer reviewed

First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report

Kyle A. Merrill, Kelli A. Krallman, Daniel Loeb, Stephen W. Standage, Dawn Mattoon, Dandan Shan, Stuart L. Goldstein and Meredith P. Schuh

Case reports in nephrology and dialysis, Vol.13(1), pp.1-6

01/27/2023

DOI: 10.1159/000527290

PMCID: PMC9891843

PMID: 36741548

Files and links (1)

url

https://doi.org/10.1159/000527290View

Published (Version of record) Open Access

Abstract

The Seraph® 100 Microbind® Affinity Blood Filter (Seraph® 100) is a hemoperfusion device designed to adsorb bacteria, viruses, and toxins when added to extracorporeal circuits. The FDA granted emergency use authorization in adults, but this device had never been utilized in children. A 17-year-old patient with asthma presented with respiratory distress due to COVID-19. His course was complicated by respiratory failure, rhabdomyolysis, and stage 3 AKI requiring initiation of continuous kidney replacement therapy (CKRT) on ICU day 3. The Seraph® 100 filter was added on ICU day 4. He was treated with 3 filters from ICU day 4 to 8. On ICU day 8, he was extubated and CKRT discontinued. He required no further kidney replacement therapy but did not have laboratory work post-discharge. In conclusion, this adolescent patient with COVID-19 and AKI requiring CKRT tolerated treatment with the Seraph® 100 Microbind® Affinity Blood Filter without significant adverse events.

Details

Title: Subtitle: First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report
Creators: Kyle A. Merrill - a
Kelli A. Krallman
Daniel Loeb
Stephen W. Standage
Dawn Mattoon
Dandan Shan
Stuart L. Goldstein
Meredith P. Schuh
Resource Type: Journal article
Publication Details: Case reports in nephrology and dialysis, Vol.13(1), pp.1-6
DOI: 10.1159/000527290
PMID: 36741548
PMCID: PMC9891843
NLM abbreviation: Case Rep Nephrol Dial
ISSN: 2296-9705
eISSN: 2296-9705
Language: English
Date published: 01/27/2023
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
Record Identifier: 9984363380302771

Metrics

13 Record Views

6 Times Cited - Web of Science

See more details