Journal article
First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy
Physica medica, Vol.88, pp.104-110
08/2021
DOI: 10.1016/j.ejmp.2021.06.017
PMCID: PMC8403156
PMID: 34218199
Abstract
•Respiration-induced positional changes impact the accuracy of radiotherapy.•MR-compatible, 4D ultrasound probe for motion management of radiotherapy developed.•Hands-free ultrasound probe to monitor the motion in the abdominal region.•Minimal susceptibility artifacts in MR from probe in images of volunteers.•Ultrasound and MR-based motion tracking demonstrated good concordance.
Respiration-induced tumor or organ positional changes can impact the accuracy of external beam radiotherapy. Motion management strategies are used to account for these changes during treatment. The authors report on the development, testing, and first-in-human evaluation of an electronic 4D (e4D) MR-compatible ultrasound probe that was designed for hands-free operation in a MR and linear accelerator (LINAC) environment.
Ultrasound components were evaluated for MR compatibility. Electromagnetic interference (EMI) shielding was used to enclose the entire probe and a factory-fabricated cable shielded with copper braids was integrated into the probe. A series of simultaneous ultrasound and MR scans were acquired and analyzed in five healthy volunteers.
The ultrasound probe led to minor susceptibility artifacts in the MR images immediately proximal to the ultrasound probe at a depth of <10 mm. Ultrasound and MR-based motion traces that were derived by tracking the salient motion of endogenous target structures in the superior-inferior (SI) direction demonstrated good concordance (Pearson correlation coefficients of 0.95–0.98) between the ultrasound and MRI datasets.
We have demonstrated that our hands-free, e4D probe can acquire ultrasound images during a MR acquisition at frame rates of approximately 4 frames per second (fps) without impacting either the MR or ultrasound image quality. This use of this technology for interventional procedures (e.g. biopsies and drug delivery) and motion compensation during imaging are also being explored.
Details
- Title: Subtitle
- First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy
- Creators
- Bryan P. Bednarz - University of Wisconsin–MadisonSydney Jupitz - University of Wisconsin–MadisonWarren Lee - GE Global Research (United States)David Mills - GE Global Research (United States)Heather Chan - GE Global Research (United States)Timothy Fiorillo - GE Global Research (United States)James Sabitini - GE Global Research (United States)David Shoudy - GE Global Research (United States)Aqsa Patel - GE Global Research (United States)Jhimli Mitra - GE Global Research (United States)Shourya Sarcar - GE Global Research (United States)Bo Wang - GE Global Research (United States)Andrew Shepard - University of Wisconsin–MadisonCharles Matrosic - University of Wisconsin–MadisonJames Holmes - University of Wisconsin–MadisonWesley Culberson - University of Wisconsin–MadisonMichael Bassetti - University of Wisconsin–MadisonPatrick Hill - University of Wisconsin–MadisonAlan McMillan - University of Wisconsin–MadisonJames Zagzebski - University of Wisconsin–MadisonL. Scott Smith - GE Global Research (United States)Thomas K. Foo - GE Global Research (United States)
- Resource Type
- Journal article
- Publication Details
- Physica medica, Vol.88, pp.104-110
- DOI
- 10.1016/j.ejmp.2021.06.017
- PMID
- 34218199
- PMCID
- PMC8403156
- NLM abbreviation
- Phys Med
- ISSN
- 1120-1797
- eISSN
- 1724-191X
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000054, name: National Cancer Institute, award: R01CA190298; DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984294923902771
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