Journal article
First total synthesis of (+)-vedelianin, a potent antiproliferative agent
Tetrahedron letters, Vol.52(14), pp.1628-1630
2011
DOI: 10.1016/j.tetlet.2011.01.137
PMCID: PMC3204860
PMID: 22053119
Abstract
The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S, 3R, 4aR, 9aR)-isomer.
Details
- Title: Subtitle
- First total synthesis of (+)-vedelianin, a potent antiproliferative agent
- Creators
- Joseph J TopczewskiDavid F Wiemer
- Resource Type
- Journal article
- Publication Details
- Tetrahedron letters, Vol.52(14), pp.1628-1630
- DOI
- 10.1016/j.tetlet.2011.01.137
- PMID
- 22053119
- PMCID
- PMC3204860
- NLM abbreviation
- Tetrahedron Lett
- ISSN
- 0040-4039
- eISSN
- 1873-3581
- Language
- English
- Date published
- 2011
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9983985950302771
Metrics
19 Record Views