Fitting Pieces into the Puzzle of Pseudomonas aeruginosa Type III Secretion System Gene Expression

Emily A Williams McMackin; Louise Djapgne; Jodi M Corley; Timothy L Yahr

doi:10.1128/JB.00209-19

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Fitting Pieces into the Puzzle of Pseudomonas aeruginosa Type III Secretion System Gene Expression

Journal article

Open access

Peer reviewed

Fitting Pieces into the Puzzle of Pseudomonas aeruginosa Type III Secretion System Gene Expression

Emily A Williams McMackin, Louise Djapgne, Jodi M Corley and Timothy L Yahr

Journal of bacteriology, Vol.201(13), p.1

07/01/2019

DOI: 10.1128/JB.00209-19

PMCID: PMC6560140

PMID: 31010903

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https://europepmc.org/articles/pmc6560140View

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Abstract

Type III secretion systems (T3SS) are widely distributed in Gram-negative microorganisms and critical for host-pathogen and host-symbiont interactions with plants and animals. Central features of the T3SS are a highly conserved set of secretion and translocation genes and contact dependence wherein host-pathogen interactions trigger effector protein delivery and serve as an inducing signal for T3SS gene expression. In addition to these conserved features, there are pathogen-specific properties that include a unique repertoire of effector genes and mechanisms to control T3SS gene expression. The T3SS serves as a model system to understand transcriptional and posttranscriptional mechanisms involved in the control of T3SS gene expression. The central regulatory feature is a partner-switching system that controls the DNA-binding activity of ExsA, the primary regulator of T3SS gene expression. Superimposed upon the partner-switching mechanism are cyclic AMP and cyclic di-GMP signaling systems, two-component systems, global regulators, and RNA-binding proteins that have positive and negative effects on ExsA transcription and/or synthesis. In the present review, we discuss advances in our understanding of how these regulatory systems orchestrate the activation of T3SS gene expression in the context of acute infections and repression of the T3SS as adapts to and colonizes the cystic fibrosis airways.

Animals

Bacterial Proteins - genetics

Gene Expression Regulation, Bacterial

Humans

Promoter Regions, Genetic

Pseudomonas aeruginosa - genetics

Pseudomonas aeruginosa - pathogenicity

Second Messenger Systems

Signal Transduction

Trans-Activators - genetics

Transcription, Genetic

Type III Secretion Systems - genetics

Details

Title: Subtitle: Fitting Pieces into the Puzzle of Pseudomonas aeruginosa Type III Secretion System Gene Expression
Creators: Emily A Williams McMackin - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA
Louise Djapgne - University of Iowa
Jodi M Corley - University of Iowa
Timothy L Yahr - University of Iowa
Resource Type: Journal article
Publication Details: Journal of bacteriology, Vol.201(13), p.1
DOI: 10.1128/JB.00209-19
PMID: 31010903
PMCID: PMC6560140
NLM abbreviation: J Bacteriol
ISSN: 0021-9193
eISSN: 1098-5530
Grant note: T32 AI007511 / NIAID NIH HHS T32 AI007343 / NIAID NIH HHS R01 AI055042 / NIAID NIH HHS P30 DK054759 / NIDDK NIH HHS
Language: English
Date published: 07/01/2019
Academic Unit: Microbiology and Immunology
Record Identifier: 9984297328202771

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