Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates

Jessica D Kresowik; Barbara J. Stegmann; Amy E.T. Sparks; Ginny L. Ryan; Bradley J. Van Voorhis

doi:10.1016/j.fertnstert.2011.09.007

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Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates

Journal article

Open access

Peer reviewed

Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates

Jessica D Kresowik, Barbara J. Stegmann, Amy E.T. Sparks, Ginny L. Ryan and Bradley J. Van Voorhis

Fertility and sterility, Vol.96(6), pp.1367-1369

12/01/2011

DOI: 10.1016/j.fertnstert.2011.09.007

PMID: 21962964

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Abstract

<p>OBJECTIVE: To report the outcomes of a program policy instituted in 2004 mandating single-embryo transfer (mSET) for all women aged <38 >years, with at least seven zygotes, no prior failed fresh cycle at our center, and at least one good-quality blastocyst. DESIGN: Retrospective cohort study. SETTING: Academic medical center. PATIENT(S): All women 1, 1999, to May 31, 2004 (before mSET) and from June 1, 2004, to May 31, 2009 (after mSET). INTERVENTION(S): mSET policy implementation. MAIN OUTCOME MEASURE(S): Live-birth rate, multiple pregnancy rate, clinical volume, and outcomes of all mSET fresh IVF transfers were analyzed. RESULT(S): Clinical volume was unchanged between the two time groups. After implementation of mSET, live-birth rates improved from 51.1% to 55.9% and multiple-birth rates dropped from 34.8% to 17.5%. A total of 364 mSET fresh transfers were performed with a live-birth rate of 64.6% and a multiple-birth rate of 3.4%. CONCLUSION(S): A mandatory SET policy based on prognostic factors can be instituted with no drop in clinical volume and no negative effect on delivery rates. Multiple gestation rates can be dramatically lowered.</p>

Pregnancy

Obstetrics and Gynecology

Adult

Down-Regulation

Female

Fertilization in Vitro/legislation & jurisprudence

Guideline Adherence

Health Plan Implementation

Humans

Mandatory Programs/legislation & jurisprudence

Pregnancy Rate/trends

Multiple/statistics & numerical data

Single Embryo Transfer/statistics & numerical data/utilization

Time Factors

Twins/statistics & numerical data

Details

Title: Subtitle: Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates
Creators: Jessica D Kresowik
Barbara J. Stegmann
Amy E.T. Sparks - University of Iowa
Ginny L. Ryan - University of Iowa
Bradley J. Van Voorhis - University of Iowa
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.96(6), pp.1367-1369
DOI: 10.1016/j.fertnstert.2011.09.007
PMID: 21962964
NLM abbreviation: Fertil Steril
ISSN: 1556-5653
Language: English
Date published: 12/01/2011
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557420702771

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