Journal article
Floret-like multinucleated giant cells in a neurofibromatosis type 1-associated neurofibroma
The American journal of dermatopathology, Vol.30(6), pp.632-634
12/2008
DOI: 10.1097/DAD.0b013e318174e73f
PMID: 19033946
Abstract
I report herein a case of floret-like multinucleated giant cells (FMGCs) in a neurofibroma (NF) from a patient with neurofibromatosis type 1 (NF1). CD34-positive FMGCs have been described in 2 prior cases of cutaneous NF and in gynecomastia from patients with NF1. In the case of NFs with FMGCs, these CD34-positive cells may represent endoneurial dendritic cells distinct from both fibroblasts and Schwann cells and do not represent degenerative or malignant change. However, the exact origin of these cells is debatable. I encourage others to observe for the presence of CD34-positive FMGCs in NFs to determine whether they are an incidental finding or are specific to NFs in patients with NF1.
Details
- Title: Subtitle
- Floret-like multinucleated giant cells in a neurofibromatosis type 1-associated neurofibroma
- Creators
- Brian L Swick - Department of Dermatology and Pathology, University of Iowa, Iowa City, IA 52242-1090, USA. swickbrian@yahoo.com
- Resource Type
- Journal article
- Publication Details
- The American journal of dermatopathology, Vol.30(6), pp.632-634
- Publisher
- United States
- DOI
- 10.1097/DAD.0b013e318174e73f
- PMID
- 19033946
- ISSN
- 0193-1091
- eISSN
- 1533-0311
- Language
- English
- Date published
- 12/2008
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984025477102771
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