Journal article
Fluid Dynamic Analysis in a Human Left Anterior Descending Coronary Artery with Arterial Motion
Annals of biomedical engineering, Vol.32(12), pp.1628-1641
12/2004
DOI: 10.1007/s10439-004-7816-3
PMID: 15675676
Abstract
A computational fluid dynamic (CFD) analysis is presented to describe local flow dynamics in both 3-D spatial and 4-D spatial and temporal domains from reconstructions of intravascular ultrasound (IVUS) and bi-plane angiographic fusion images. A left anterior descending (LAD) coronary artery segment geometry was accurately reconstructed and subsequently its motion was incorporated into the CFD model. The results indicate that the incorporation of motion had appreciable effects on blood flow patterns. The velocity profiles in the region of a stenosis and the circumferential distribution of the axial wall shear stress (WSS) patterns in the vessel are altered with the wall motion introduced in the simulation. The time-averaged axial WSS between simulations of steady flow and unsteady flow without arterial motion were comparable (−0.3 to 13.7 Pa in unsteady flow versus −0.2 to 10.1 Pa in steady flow) while the magnitudes decreased when motion was introduced (0.3–4.5 Pa). The arterial wall motion affects the time-mean WSS and the oscillatory shear index in the coronary vessel fluid dynamics and may provide more realistic predictions on the progression of atherosclerotic disease.
Details
- Title: Subtitle
- Fluid Dynamic Analysis in a Human Left Anterior Descending Coronary Artery with Arterial Motion
- Creators
- S. D Ramaswamy - Department of Biomedical Engineering University of Iowa Iowa City IAS Vigmostad - Department of Biomedical Engineering University of Iowa Iowa City IAA Wahle - Department of Electrical and Computer Engineering University of Iowa Iowa City IAY Lai - IIHR-Hydroscience and Engineering University of Iowa Iowa City IAM Olszewski - Department of Electrical and Computer Engineering University of Iowa Iowa City IAK Braddy - Department of Internal Medicine University of Iowa Iowa City IAT Brennan - Department of Internal Medicine University of Iowa Iowa City IAJ Rossen - Department of Internal Medicine University of Iowa Iowa City IAM Sonka - Department of Electrical and Computer Engineering University of Iowa Iowa City IAK Chandran - IIHR-Hydroscience and Engineering University of Iowa Iowa City IA
- Resource Type
- Journal article
- Publication Details
- Annals of biomedical engineering, Vol.32(12), pp.1628-1641
- DOI
- 10.1007/s10439-004-7816-3
- PMID
- 15675676
- NLM abbreviation
- Ann Biomed Eng
- ISSN
- 0090-6964
- eISSN
- 1573-9686
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- Language
- English
- Date published
- 12/2004
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Electrical and Computer Engineering; Cardiovascular Medicine; Surgery; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Neurosurgery; Mechanical Engineering; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047773602771
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