Journal article
Fluid replacement protection of rabbits challenged subcutaneously with toxic shock syndrome toxins
Infection and immunity, Vol.59(3), pp.879-884
01/01/1991
DOI: 10.1128/IAI.59.3.879-884.1991
PMID: 1997438
Abstract
Toxic shock syndrome toxin 1 (TSST-1) and streptococcal pyrogenic exotoxin A (SPE A) belong to a family of pyrogenic toxins produced by Staphylococcus aureus and Streptococcus pyogenes , respectively. Both toxins are responsible for causing toxic shock syndrome (TSS) and related illnesses, clinically characterized by multiorgan involvement. The most severe TSS symptom is acute hypotension and shock after the initial febrile response. In this study, we examined possible mechanisms of shock development in TSS, particularly the role of T-cell proliferation, endotoxin enhancement by toxins, and capillary leakage. The data suggest that toxin interactions causing vascular leakage and to some extent endotoxin enhancement are of major importance in development of hypotension and shock in TSS. It appears that T-cell proliferation may not contribute significantly to the induction of shock and death.
Details
- Title: Subtitle
- Fluid replacement protection of rabbits challenged subcutaneously with toxic shock syndrome toxins
- Creators
- Peter K LeeJames R DeringerBarry N KreiswirthRichard P NovickPatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.59(3), pp.879-884
- DOI
- 10.1128/IAI.59.3.879-884.1991
- PMID
- 1997438
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Language
- English
- Date published
- 01/01/1991
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001153502771
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