Journal article
Fluid transport across the canine tracheal epithelium
Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.49(5), pp.905-909
11/1980
DOI: 10.1152/jappl.1980.49.5.905
PMID: 7429914
Abstract
We measured the rate of fluid movement across the tracheal epithelium of the dog by an electrical method, modified from that originally described by Wiedner (Rev. Sci. Instrum. 47: 775-6, 1976). The base-line volume flow (Jv) from the submucosa to the mucosa was 44 +/- 23 nl.min-1.cm-2 (mean +/- SE; n = 6). In only three of the tissues was the resting Jv significantly greater than zero. Stimulation with 2 X 10(-3) M aminophylline (a drug that we have shown stimulates Cl secretion under short-circuit conditions) increased Jv in all tissues to a mean of 137 +/- 29 nl.min-1.cm-2 (P < 0.001). We also measured the unidirectional fluxes of Cl with the tissue at its spontaneous electrical potential. During the base-line period, the net flux of Cl was not significantly different from zero. During stimulation with aminophylline, Cl secretion increased to a mean of 1.44 +/- 0.50 microneq.cm-2.h-1. Comparison of the stimulated values of Jv and net Cl secretion suggests that fluid secretion by the trachea is isotonic during stimulation with aminophylline.
Details
- Title: Subtitle
- Fluid transport across the canine tracheal epithelium
- Creators
- M J WelshJ H WiddicombeJ A Nadel
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology: respiratory, environmental and exercise physiology, Vol.49(5), pp.905-909
- Publisher
- United States
- DOI
- 10.1152/jappl.1980.49.5.905
- PMID
- 7429914
- ISSN
- 0161-7567
- eISSN
- 2691-2465
- Grant note
- HL-07159 / NHLBI NIH HHS HL-06285 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/1980
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020993402771
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