Fluorescence Imaging Topography Scanning System for intraoperative multimodal imaging

Tri T Quang; Hye-Yeong Kim; Forrest Sheng Bao; Francis A Papay; W Barry Edwards; Yang Liu

doi:10.1371/journal.pone.0174928

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Fluorescence Imaging Topography Scanning System for intraoperative multimodal imaging

Journal article

Open access

Peer reviewed

Fluorescence Imaging Topography Scanning System for intraoperative multimodal imaging

Tri T Quang, Hye-Yeong Kim, Forrest Sheng Bao, Francis A Papay, W Barry Edwards and Yang Liu

PloS one, Vol.12(4), pp.e0174928-e0174928

2017

DOI: 10.1371/journal.pone.0174928

PMCID: PMC5402944

PMID: 28437441

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https://doi.org/10.1371/journal.pone.0174928View

Published (Version of record) Open Access

Abstract

Fluorescence imaging is a powerful technique with diverse applications in intraoperative settings. Visualization of three dimensional (3D) structures and depth assessment of lesions, however, are oftentimes limited in planar fluorescence imaging systems. In this study, a novel Fluorescence Imaging Topography Scanning (FITS) system has been developed, which offers color reflectance imaging, fluorescence imaging and surface topography scanning capabilities. The system is compact and portable, and thus suitable for deployment in the operating room without disturbing the surgical flow. For system performance, parameters including near infrared fluorescence detection limit, contrast transfer functions and topography depth resolution were characterized. The developed system was tested in chicken tissues ex vivo with simulated tumors for intraoperative imaging. We subsequently conducted in vivo multimodal imaging of sentinel lymph nodes in mice using FITS and PET/CT. The PET/CT/optical multimodal images were co-registered and conveniently presented to users to guide surgeries. Our results show that the developed system can facilitate multimodal intraoperative imaging.

Animals

Chickens

Lymph Nodes - diagnostic imaging

Mice

Monitoring, Intraoperative - methods

Multimodal Imaging - methods

Optical Imaging

Positron Emission Tomography Computed Tomography

Details

Title: Subtitle: Fluorescence Imaging Topography Scanning System for intraoperative multimodal imaging
Creators: Tri T Quang - University of Akron
Hye-Yeong Kim - University of Pittsburgh
Forrest Sheng Bao - University of Akron
Francis A Papay - Cleveland Clinic
W Barry Edwards - University of Pittsburgh
Yang Liu - University of Akron
Resource Type: Journal article
Publication Details: PloS one, Vol.12(4), pp.e0174928-e0174928
DOI: 10.1371/journal.pone.0174928
PMID: 28437441
PMCID: PMC5402944
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Language: English
Date published: 2017
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984197447802771

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