Journal article
Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review
Advances in anatomic pathology, Vol.16(6), pp.383-391
11/2009
DOI: 10.1097/PAP.0b013e3181bb6b86
PMID: 19851129
Abstract
This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which can be assessed by FISH, and can be used to assist in their diagnosis. We discuss the major morphologic categories in which FISH has come to be used including high-grade round cell sarcomas, spindle cell sarcomas, low-grade myxoid neoplasms, adipocytic neoplasms, and malignant melanocytic neoplasms on the basis of a recent review of soft tissue neoplasms which were analyzed by FISH. We also review the molecular alterations (translocations and amplification of gene regions), which have come to define many of these diagnostic entities and the most effective way to evaluate them with FISH with attention to potential pitfalls. Finally, we discuss the advantages and disadvantages of FISH as a technique when appraising soft tissue neoplasms.
Details
- Title: Subtitle
- Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review
- Creators
- Munir R Tanas - Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USAJohn R Goldblum
- Resource Type
- Journal article
- Publication Details
- Advances in anatomic pathology, Vol.16(6), pp.383-391
- Publisher
- United States
- DOI
- 10.1097/PAP.0b013e3181bb6b86
- PMID
- 19851129
- ISSN
- 1072-4109
- eISSN
- 1533-4031
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984046914102771
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