Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study

Reem Reda Oweis; Steven M Levy; Julie M Eichenberger-Gilmore; John J Warren; Trudy L Burns; Kathleen F Janz; James C Torner; Punam K Saha; Elena Letuchy

doi:10.1111/cdoe.12373

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Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study

Journal article

Peer reviewed

Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study

Reem Reda Oweis, Steven M Levy, Julie M Eichenberger-Gilmore, John J Warren, Trudy L Burns, Kathleen F Janz, James C Torner, Punam K Saha and Elena Letuchy

Community dentistry and oral epidemiology, Vol.46(6), pp.527-534

12/2018

DOI: 10.1111/cdoe.12373

PMCID: PMC6237627

PMID: 29962091

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Abstract

To investigate the associations between period-specific and cumulative fluoride (F) intakes from birth to age 17 years, and radial and tibial bone measures obtained using peripheral quantitative computed tomography (pQCT). Participants (n = 380) were recruited from hospitals at birth and continued their participation in the ongoing Iowa Fluoride Study/Iowa Bone Development Study until age 17. Fluoride intakes from water, other beverages, selected foods, dietary fluoride supplements and dentifrice were determined every 1.5-6 months using detailed questionnaires. Associations between F intake and bone measures (cortical and trabecular bone mineral content [BMC], density and strength) were determined in bivariate and multivariable analyses adjusted for height, weight, maturity offset, physical activity, and daily calcium and protein intake using robust regression analysis. Fluoride intake ranged from 0.7 to 0.8 mg F/d for females and from 0.7 to 0.9 mg F/d for males. Spearman correlations between daily F intake and pQCT bone measures were weak. For females, Spearman correlations ranged from r = -.08 to .21, and for males, they ranged from r = -.03 to .30. In sex-specific, height-, weight- and maturity offset- partially adjusted regression analyses, associations between females' fluoride intake and bone characteristics were almost all negative; associations for males were mostly positive. In the fully adjusted models, which also included physical activity, and protein and calcium intakes, no significant associations were detected for females; significant positive associations were detected between F intake from 14 to 17 years and tibial cortical bone content (β = 21.40, P < .01) and torsion strength (β = 175.06, P < .01) for males. In this cohort of 17-year-old adolescents, mostly living in optimally fluoridated areas, lifelong F intake from combined sources was weakly associated with bone pQCT measures.

Prospective Studies

Humans

Child, Preschool

Infant

Male

Tomography, X-Ray Computed

Cancellous Bone - drug effects

Cancellous Bone - diagnostic imaging

Dietary Proteins - pharmacology

Cortical Bone - growth & development

Radius - drug effects

Female

Tibia - growth & development

Calcium, Dietary - pharmacology

Child

Infant, Newborn

Bone Development - drug effects

Cancellous Bone - growth & development

Tibia - diagnostic imaging

Tibia - drug effects

Fluorides - pharmacology

Bone Density - drug effects

Radius - growth & development

Adolescent

Cortical Bone - drug effects

Sex Factors

Cortical Bone - diagnostic imaging

Radius - diagnostic imaging

Details

Title: Subtitle: Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study
Creators: Reem Reda Oweis - Department of Preventive and Community Dentistry, College of Dentistry, Iowa City, IA, USA
Steven M Levy - Department of Epidemiology, College of Public Health, Iowa City, IA, USA
Julie M Eichenberger-Gilmore - Nutrition and Food Services, Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA
John J Warren - Department of Preventive and Community Dentistry, College of Dentistry, Iowa City, IA, USA
Trudy L Burns - Department of Epidemiology, College of Public Health, Iowa City, IA, USA
Kathleen F Janz - Department of Health and Human Physiology, College of Liberal Arts and Sciences, Iowa City, IA, USA
James C Torner - Department of Epidemiology, College of Public Health, Iowa City, IA, USA
Punam K Saha - Department of Electrical and Computer Engineering, College of Engineering, The University of Iowa, Iowa City, IA, USA
Elena Letuchy - Department of Epidemiology, College of Public Health, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Community dentistry and oral epidemiology, Vol.46(6), pp.527-534
DOI: 10.1111/cdoe.12373
PMID: 29962091
PMCID: PMC6237627
NLM abbreviation: Community Dent Oral Epidemiol
ISSN: 0301-5661
eISSN: 1600-0528
Publisher: Denmark
Grant note: UL1 RR024979 / NCRR NIH HHS R01 DE012101 / NIDCR NIH HHS M01 RR000059 / NCRR NIH HHS R56 DE012101 / NIDCR NIH HHS R01 DE009551 / NIDCR NIH HHS
Language: English
Date published: 12/2018
Academic Unit: Preventive and Community Dentistry; Radiology; Electrical and Computer Engineering; Epidemiology; Surgery; Pediatric Dentistry; Injury Prevention Research Center; Neurosurgery; Health, Sport, and Human Physiology
Record Identifier: 9983917667802771

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