Fluoroquinolone resistance in Streptococcus pyogenes

Sandra S Richter; Daniel J Diekema; Kris P Heilmann; Laurel S Almer; Virginia D Shortridge; Rod Zeitler; Robert K Flamm; Gary V Doern

doi:10.1086/345904

Back

Fluoroquinolone resistance in Streptococcus pyogenes

Journal article

Open access

Peer reviewed

Fluoroquinolone resistance in Streptococcus pyogenes

Sandra S Richter, Daniel J Diekema, Kris P Heilmann, Laurel S Almer, Virginia D Shortridge, Rod Zeitler, Robert K Flamm and Gary V Doern

Clinical infectious diseases, Vol.36(3), pp.380-383

02/01/2003

DOI: 10.1086/345904

PMID: 12539083

Files and links (1)

url

https://doi.org/10.1086/345904View

Published (Version of record) Open Access

Abstract

Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 microg/mL) was found. DNA amplification and sequencing revealed a serine81-->tyrosine substitution in gyrA and 2 substitutions in parC: serine79-->phenylalanine and alanine121-->valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.

Levofloxacin

Streptococcal Infections - microbiology

Streptococcus pyogenes - drug effects

Anti-Infective Agents - pharmacology

Humans

Microbial Sensitivity Tests

Streptococcus pyogenes - genetics

Streptococcus pyogenes - isolation & purification

Ofloxacin - pharmacology

DNA Gyrase - genetics

Female

DNA Topoisomerase IV - genetics

Drug Resistance, Bacterial - genetics

Amino Acid Substitution

Details

Title: Subtitle: Fluoroquinolone resistance in Streptococcus pyogenes
Creators: Sandra S Richter - Department of Pathology, University of Iowa Healthcare, Iowa City, Iowa 52242, USA. sandra-richter@uiowa.edu
Daniel J Diekema
Kris P Heilmann
Laurel S Almer
Virginia D Shortridge
Rod Zeitler
Robert K Flamm
Gary V Doern
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.36(3), pp.380-383
Publisher: United States
DOI: 10.1086/345904
PMID: 12539083
ISSN: 1058-4838
eISSN: 1537-6591
Language: English
Date published: 02/01/2003
Academic Unit: Infectious Diseases; Epidemiology; Pathology; General Internal Medicine; Internal Medicine
Record Identifier: 9983986364902771

Metrics

17 Record Views

31 Times Cited - Web of Science