Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Alexandre Leme Godoy-Santos; Homero Bruschini; Jose Cury; Miguel Srougi; Cesar de Cesar-Netto; Lucas F Fonseca; Nicola Maffulli

doi:10.1016/j.urology.2017.10.017

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Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Journal article

Open access

Peer reviewed

Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Alexandre Leme Godoy-Santos, Homero Bruschini, Jose Cury, Miguel Srougi, Cesar de Cesar-Netto, Lucas F Fonseca and Nicola Maffulli

Urology (Ridgewood, N.J.), Vol.113, pp.20-25

03/2018

DOI: 10.1016/j.urology.2017.10.017

PMID: 29074337

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Abstract

To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment. Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017. A total of 79 articles were used, with ciprofloxacin representing the most common drug. We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders.

Severity of Illness Index

Achilles Tendon - pathology

Urinary Tract Infections - diagnosis

Age Factors

Follow-Up Studies

Rupture, Spontaneous - chemically induced

Rupture, Spontaneous - epidemiology

Humans

Middle Aged

Tendinopathy - epidemiology

Fluoroquinolones - therapeutic use

Male

Achilles Tendon - injuries

Tendinopathy - chemically induced

Case-Control Studies

Fluoroquinolones - adverse effects

Urinary Tract Infections - drug therapy

Incidence

Sex Factors

Adult

Female

Retrospective Studies

Tendinopathy - physiopathology

Details

Title: Subtitle: Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication
Creators: Alexandre Leme Godoy-Santos - Department of Orthopaedics and Traumatology, University of São Paulo, São Paulo, São Paulo, Brazil. Electronic address: alexandrelemegodoy@gmail.com
Homero Bruschini - Department of Urology, University of São Paulo, São Paulo, São Paulo, Brazil
Jose Cury - Department of Urology, University of São Paulo, São Paulo, São Paulo, Brazil
Miguel Srougi - Department of Urology, University of São Paulo, São Paulo, São Paulo, Brazil
Cesar de Cesar-Netto - Department of Orthopedics Foot and Ankle Surgery, Hospital for Special Surgery (HSS), New York, NY
Lucas F Fonseca - Department of Orthopedics Foot and Ankle Surgery, Hospital for Special Surgery (HSS), New York, NY
Nicola Maffulli - Department of Orthopaedics and Traumatology, Azienda Ospedaliera San Giovanni di Dio e Ruggi d'Aragona, University of Salerno, Salerno, Italy; Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, London, United Kingdom
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.113, pp.20-25
DOI: 10.1016/j.urology.2017.10.017
PMID: 29074337
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Publisher: United States
Language: English
Date published: 03/2018
Academic Unit: Orthopedics and Rehabilitation
Record Identifier: 9984040336802771

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