Journal article
Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis
International journal of cardiology, Vol.274(3), pp.299-302
01/01/2019
DOI: 10.1016/j.ijcard.2018.09.067
PMID: 30309682
Abstract
Objective: To investigate the association between fluoroquinolones use and development of aortopathy.
Methods: A systematic review and meta-analysis was conducted following PRISMA and MOOSE guidelines for reporting systematic reviews of observational studies. Multiple databases were searched and two authors independently screened studies for eligibility. Newcastle Ottawa scale was used to assessed the quality of included studies. Primary outcome of interest was development of aortic aneurysm or dissection among fluoroquinolones users in comparison to non-users. An inverse variance model meta-analysis was used to pool odds ratio or hazards ratio from included studies to calculate the overall effect estimate. Pre specified subgroups analyses were also conducted to explore sources of heterogeneity.
Results: Three observational studies that enrolled 941,639 subjects met the inclusion criteria and were included in the final analysis. All studies were of a good methodological quality. Current use of fluoroquinolones, defined as within 60 days from development of the primary outcome, was associated with significantly elevated risk of developing aortic aneurysm and/or dissection in comparison to controls, (OR = 2.04; 95% CI [1.67, 2.48]). There was only a mild degree of between study heterogeneity, I-2 = 33%. The association remains robust among all subgroups analyses.
Conclusion: Our findings indicate that current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection. Health care providers need to be aware of this serious association and use fluoroquinolones judiciously in order to minimize the risk of the serious sequela of aortopathy. (c) 2018 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis
- Creators
- Anas T. Noman - University of Missouri–Kansas CityAbdul H. Qazi - Roy J. and Lucille A. Carver College of MedicineMusab Alqasrawi - Roy J. and Lucille A. Carver College of MedicineHakeem Ayinde - Roy J. and Lucille A. Carver College of MedicineImad M. Tleyjeh - Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USAPaul Lindower - Roy J. and Lucille A. Carver College of MedicineAref A. Bin Abdulhak - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.274(3), pp.299-302
- DOI
- 10.1016/j.ijcard.2018.09.067
- PMID
- 30309682
- NLM abbreviation
- Int J Cardiol
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Publisher
- Elsevier
- Number of pages
- 4
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318786902771
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