Journal article
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor
The Journal of immunology (1950), Vol.191(12), pp.6208-6221
12/15/2013
DOI: 10.4049/jimmunol.1301587
PMCID: PMC3865716
PMID: 24227778
Abstract
Focal adhesion kinase (FAK) is a critical regulator of signal transduction in multiple cell types. Although this protein is activated upon T cell receptor (TCR) engagement, the cellular function that FAK plays in mature human T cells is unknown. By suppressing the function of FAK, we revealed that FAK inhibits TCR-mediated signaling by recruiting C-terminal Src kinase (Csk) to the membrane and/or receptor complex following TCR activation. Thus, in the absence of FAK, the inhibitory phosphorylation of Lck and/or Fyn is impaired. Together, these data highlight a novel role for FAK as a negative regulator TCR function in human T cells. These results also suggest that changes in FAK expression could modulate sensitivity to TCR stimulation and contribute to the progression of T cell malignancies and autoimmune diseases.
Details
- Title: Subtitle
- Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor
- Creators
- Nicole M Chapman - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, United StatesSean F Connolly - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, United StatesErin L Reinl - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United StatesJon C.D Houtman - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.191(12), pp.6208-6221
- DOI
- 10.4049/jimmunol.1301587
- PMID
- 24227778
- PMCID
- PMC3865716
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- R01 CA136729 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 12/15/2013
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984094320102771
Metrics
30 Record Views