Journal article
Focal microsatellite mutations in relatives with prostatic adenocarcinoma
Anticancer research, Vol.16(6B), pp.3883-3886
1996
PMID: 9042275
Abstract
Instability of short tandem repeat sequences, microsatellite instability (MI), has been reported to play an important role in the tumorigenesis of various adenocarcinomas, including prostatic adenocarcinoma. Although prostate cancer is not widely recognized as a heriditary cancer, familial clustering is well known. To investigate the frequency of microsatellite instability in familial prostatic adenocarcinomas we analyzed archival tumor tissue from seven paired first degree relatives with prostatic adenocarcinoma. Twelve dinucleotide, nine trinucleotide, six tetranucleotide repeats and the CAG repeat of the androgen receptor gene were screened for MI. Solitary mutations were observed in four separate cases (28.6%) and widespread somatic alterations were not identified. No statistical correlation to pathological characteristics was determined. Our data indicate that microsatellite instability is an uncommon phenomenon in prostatic adenocarcinoma within first degree relatives. Those changes present appear to manifest as focal mutations in contrast to the more global changes seen in MI.
Details
- Title: Subtitle
- Focal microsatellite mutations in relatives with prostatic adenocarcinoma
- Creators
- A. H WILLE - Department of Urology, University Hospital (Charité), Humboldt-University, Berlin, GermanyR. B TERRELL - Department of Urology, University of Iowa, Iowa City, Iowa, United StatesJ. C CHEVILLE - Department of Pathology, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa, United StatesV. C SHEFFIELD - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United StatesM. B COHEN - Department of Pathology, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Anticancer research, Vol.16(6B), pp.3883-3886
- Publisher
- International Institute of Anticancer Research; Attiki
- PMID
- 9042275
- ISSN
- 0250-7005
- eISSN
- 1791-7530
- Language
- English
- Date published
- 1996
- Academic Unit
- Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984065397202771
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