Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance

Kartik K Iyer; Kai Hwang; Luke J Hearne; Eli Muller; Mark D'Esposito; James M Shine; Luca Cocchi

doi:10.1038/s41467-021-26978-2

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Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance

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Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance

Kartik K Iyer, Kai Hwang, Luke J Hearne, Eli Muller, Mark D'Esposito, James M Shine and Luca Cocchi

Nature communications, Vol.13(1), pp.4-4

01/10/2022

DOI: 10.1038/s41467-021-26978-2

PMCID: PMC8749005

PMID: 35013147

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Abstract

The emergence of distributed patterns of neural activity supporting brain functions and behavior can be understood by study of the brain's low-dimensional topology. Functional neuroimaging demonstrates that brain activity linked to adaptive behavior is constrained to low-dimensional manifolds. In human participants, we tested whether these low-dimensional constraints preserve working memory performance following local neuronal perturbations. We combined multi-session functional magnetic resonance imaging, non-invasive transcranial magnetic stimulation (TMS), and methods translated from the fields of complex systems and computational biology to assess the functional link between changes in local neural activity and the reshaping of task-related low dimensional trajectories of brain activity. We show that specific reconfigurations of low-dimensional trajectories of brain activity sustain effective working memory performance following TMS manipulation of local activity on, but not off, the space traversed by these trajectories. We highlight an association between the multi-scale changes in brain activity underpinning cognitive function.

Details

Title: Subtitle: Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance
Creators: Kartik K Iyer - QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. Kartik.Iyer@qimrberghofer.edu.au
Kai Hwang - Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720-1650, USA
Luke J Hearne - QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia
Eli Muller - The University of Sydney, Sydney, NSW, 2050, Australia
Mark D'Esposito - Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720-1650, USA
James M Shine - The University of Sydney, Sydney, NSW, 2050, Australia
Luca Cocchi - QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. Luca.Cocchi@qimrberghofer.edu.au
Resource Type: Journal article
Publication Details: Nature communications, Vol.13(1), pp.4-4
DOI: 10.1038/s41467-021-26978-2
PMID: 35013147
PMCID: PMC8749005
NLM abbreviation: Nat Commun
eISSN: 2041-1723
Grant note: F32 NS090757 / NINDS NIH HHS
Language: English
Date published: 01/10/2022
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984210344702771

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