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Focus on Data: Statistical Design of Experiments and Sample Size Selection Using Power Analysis
Journal article   Open access   Peer reviewed

Focus on Data: Statistical Design of Experiments and Sample Size Selection Using Power Analysis

Johannes Ledolter and Randy H Kardon
Investigative ophthalmology & visual science, Vol.61(8), pp.11-11
07/09/2020
DOI: 10.1167/iovs.61.8.11
PMID: 32645134
url
https://doi.org/10.1167/iovs.61.8.11View
Published (Version of record) Open Access

Abstract

Purpose: To provide information to visual scientists on how to optimally design experiments and how to select an appropriate sample size, which is often referred to as a power analysis. Methods: Statistical guidelines are provided outlining good principles of experimental design, including replication, randomization, blocking or grouping of subjects, multifactorial design, and sequential approach to experimentation. In addition, principles of power analysis for calculating required sample size are outlined for different experimental designs and examples are given for calculating power and factors influencing it. Results: The interaction between power, sample size and standardized effect size are shown. The following results are also provided: sample size increases with power, sample size increases with decreasing detectable difference, sample size increases proportionally to the variance, and two-sided tests, without preference as to whether the mean increases or decreases, require a larger sample size than one-sided tests. Conclusions: This review outlines principles for good experimental design and methods for power analysis for typical sample size calculations that visual scientists encounter when designing experiments of normal and non-Gaussian sample distributions.

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