Journal article
Follicle-stimulating hormone levels on cycle day 3 to predict ovarian response in women undergoing controlled ovarian hyperstimulation for in vitro fertilization using a flare-up protocol
Fertility and sterility, Vol.68(3), pp.483-487
1997
DOI: 10.1016/S0015-0282(97)00246-X
PMID: 9314919
Abstract
Objective: To determine whether cycle day 3 serum FSH levels predict poor ovarian response and cycle cancellation in women undergoing controlled ovarian hyperstimulation (COH) for IVF.
Design: Prospective case series.
Setting: University hospital IVF program.
Patient(s): The study includes outcomes of 637 initial cycles of IVF.
Intervention(s): Controlled ovarian hyperstimulation was undertaken with a short, flare-up GnRH agonist and hMG protocol. The relation of cycle day 3 FSH levels with various cycle characteristics and outcomes was determined.
Main Outcome Measure(s): The accuracy of cycle day 3 FSH levels in predicting poor ovarian response and cycle cancellation was evaluated. Receiver operating characteristic curves were constructed to determine the optimum cutoff value for the cycle day 3 serum FSH level that best predicted poor ovarian response and cycle cancellation.
Result(s): A cycle day 3 serum FSH level ≤13 mIU/mL (conversion factor to SI unit, 1.00) was associated with a high likelihood of poor ovarian response and cycle cancellation. The sensitivity, specificity, and positive likelihood ratio of an FSH level of 13 mIU/mL in predicting cycle cancellation were 52%, 91%, and 6.04, respectively.
Conclusion(s): Cycle day 3 FSH screening appears to be a fairly accurate predictor of poor ovarian response and cycle cancellation in women undergoing COH using a short, flare-up GnRH agonist and hMG protocol.
Details
- Title: Subtitle
- Follicle-stimulating hormone levels on cycle day 3 to predict ovarian response in women undergoing controlled ovarian hyperstimulation for in vitro fertilization using a flare-up protocol
- Creators
- Timur Gürgan - Hacettepe UniversityBulent Urman - Hacettepe UniversityHakan Yarali - Hacettepe UniversityHakan E. Duran - Hacettepe University
- Resource Type
- Journal article
- Publication Details
- Fertility and sterility, Vol.68(3), pp.483-487
- DOI
- 10.1016/S0015-0282(97)00246-X
- PMID
- 9314919
- NLM abbreviation
- Fertil Steril
- ISSN
- 0015-0282
- eISSN
- 1556-5653
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1997
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984315742202771
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