Journal article
Fonofos exposure and cancer incidence in the agricultural health study
Environmental health perspectives, Vol.114(12), pp.1838-1842
12/2006
DOI: 10.1289/ehp.9301
PMCID: PMC1764168
PMID: 17185272
Abstract
The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993-1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer.
This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS.
Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders.
Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94-5.34, Ptrend = 0.07) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06-6.70, Ptrend = 0.04), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose-response trend for lifetime exposure-days (Ptrend = 0.02, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03-3.05; RRinteraction = 1.28, 95% CI, 1.07-1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites.
Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure.
Details
- Title: Subtitle
- Fonofos exposure and cancer incidence in the agricultural health study
- Creators
- Rajeev Mahajan - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USAAaron BlairCharles F LynchPaul SchroederJane A HoppinDale P SandlerMichael C R Alavanja
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.114(12), pp.1838-1842
- Publisher
- United States
- DOI
- 10.1289/ehp.9301
- PMID
- 17185272
- PMCID
- PMC1764168
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Grant note
- Intramural NIH HHS
- Language
- English
- Date published
- 12/2006
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995037302771
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