Journal article
Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults
npj aging, Vol.11(1), 47
06/18/2025
DOI: 10.1038/s41514-025-00241-0
PMCID: PMC12177064
PMID: 40533471
Abstract
This study investigated the role of food insecurity as an effect modifier between the gut microbiome, including groups of microbes (cliques), and risk of cognitive impairment (RCI). The analytical sample (n = 360) included adult participants of the Survey of the Health of Wisconsin with complete data on food insecurity, RCI, and 16S rRNA sequencing from stool samples. Microbial cliques associated with RCI were identified using an interpretable machine-learning-based algorithm. All analyses were stratified by food insecurity level, and adjusted for relevant confounders. We identified two cliques whose associations with RCI were modified by food insecurity status. The presence of the clique with either Eisenbergiella or Eubacterium was more strongly associated with RCI for the food-insecure group (β = 0.29, p < 0.0001). A clique representing the presence of Ruminococcus torques, Bacteroides, CAG-352F, and/or Eubacterium had a stronger association with RCI for the food-secure group (β = 0.1, p < 0.0001). Findings suggest food security be considered in RCI etiology.
Details
- Title: Subtitle
- Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults
- Creators
- Shoshannah Eggers - University of IowaZachary E. Hoggarth - University of IowaKiran Nagdeo - Icahn School of Medicine at Mount SinaiMaria J. Banas - University of IowaJamil M. Lane - Icahn School of Medicine at Mount SinaiElza Rechtman - Icahn School of Medicine at Mount SinaiChris Gennings - Icahn School of Medicine at Mount SinaiElizabeth O’Neal - University of IowaPaul E. Peppard - University of Wisconsin–MadisonAjay K. Sethi - University of Wisconsin–MadisonNasia Safdar - University of Wisconsin–MadisonKristen MC Malecki - Chicago Department of Public HealthAmy A Schultz - University of Wisconsin–MadisonVishal Midya - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- npj aging, Vol.11(1), 47
- DOI
- 10.1038/s41514-025-00241-0
- PMID
- 40533471
- PMCID
- PMC12177064
- NLM abbreviation
- NPJ Aging
- ISSN
- 2731-6068
- eISSN
- 2731-6068
- Publisher
- Nature Publishing Group UK
- Grant note
- National Institute of Environmental Health SciencesUniversity of Wisconsin School of Medicine and Public Health's (UWSMPH) Wisconsin Partnership ProgramUWSMPH's Department of Medicine Pilot Award Program: P2CHD047873 National Institutes of Health: P30ES023515 Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) Pilot Project Program: P30ES005605 National Institute of Environmental Health Sciences
We would like to thank the SHOW and WMS participants and field staff, Dr. Garret Suen and his lab, as well as our funders. Funding for this work came in part from the University of Wisconsin School of Medicine and Public Health's (UWSMPH) Wisconsin Partnership Program and UWSMPH's Department of Medicine Pilot Award Program. We also acknowledge support from the National Institutes of Health core grant to the Center for Demography and Ecology at the University of Wisconsin-Madison (P2CHD047873). This project was also funded by the Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) Pilot Project Program (P30ES023515). S.E. was additionally supported by the National Institute of Environmental Health Sciences (R00ES032884). M.J.B. was additionally supported by the National Institute of Environmental Health Sciences (P30ES005605).
- Language
- English
- Date published
- 06/18/2025
- Academic Unit
- The National Advanced Driving Simulator; Epidemiology; Injury Prevention Research Center; Community and Behavioral Health
- Record Identifier
- 9984832086602771
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