Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake

Debora S A Colombari; Jose Vanderlei Menani; Alan Kim Johnson

doi:10.1152/ajpregu.1996.271.6.r1470

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Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake

Journal article

Peer reviewed

Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake

Debora S A Colombari, Jose Vanderlei Menani and Alan Kim Johnson

The American journal of physiology, Vol.271(6 Pt 2), pp.R1470-1476

12/1996

DOI: 10.1152/ajpregu.1996.271.6.r1470

PMID: 8997341

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Abstract

This study investigated the roles of serotonin (5-HT) receptors in the lateral parabrachial nucleus (LPBN) and brain angiotensin type 1 (AT1) receptors in the intake of 0.3 M NaCl and water induced by angiotensin II (ANG II). Rats were implanted with stainless steel cannulas for injections into the subfornical organ (SFO) and into the LPBN. Bilateral LPBN pretreatment with the nonselective serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (4 micrograms/200 nl) markedly enhanced 0.3 M NaCl intake induced by injections of ANG II (20 ng/200 nl) into the SFO. Pretreatment of the SFO with the AT1 receptor antagonist losartan (1 microgram/200 nl) blocked the intake of 0.3 M NaCl induced by ANG II in combination with LPBN methysergide injections. These results suggest that serotonergic mechanisms associated with the LPBN inhibit the expression of salt appetite induced by ANG II injections into the SFO. In addition, the results indicate that the enhanced NaCl intake generated by central administration of ANG II in the presence of LPBN 5-HT blockade is mediated by brain AT1 receptors.

Angiotensin I - metabolism

Angiotensin II - pharmacology

Animals

Drinking - drug effects

Drinking - physiology

Injections

Male

Methysergide - pharmacology

Prosencephalon - metabolism

Rats

Rats, Sprague-Dawley

Receptors, Angiotensin - physiology

Rhombencephalon - drug effects

Rhombencephalon - metabolism

Serotonin - physiology

Serotonin Antagonists - pharmacology

Sodium Chloride

Subfornical Organ - drug effects

Subfornical Organ - physiology

Water

Details

Title: Subtitle: Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake
Creators: Debora S A Colombari - Department of Psychology, University of Iowa, Iowa City 52242-1407, USA
Jose Vanderlei Menani
Alan Kim Johnson
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.271(6 Pt 2), pp.R1470-1476
DOI: 10.1152/ajpregu.1996.271.6.r1470
PMID: 8997341
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-14338 / NHLBI NIH HHS HL-44546 / NHLBI NIH HHS
Language: English
Date published: 12/1996
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213429302771

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