Journal article
Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats
Stroke (1970), Vol.22(8), pp.1040-1047
1991
DOI: 10.1161/01.STR.22.8.1040
PMID: 1866751
Abstract
Two groups of rats were tested on a variety of motor and cognitive tasks after either 10 minutes of two-vessel occlusion forebrain ischemia (n = 8) or sham operative procedures (n = 6). Histological injury was absent in the sham-operated group. In the ischemic group, hippocampal injury was restricted to field CA1, while damage in the neocortex and caudoputamen was sparse. Motor tests performed on postoperative days 18 and 28 revealed no significant differences between the ischemic and sham-operated groups. Retention performance of a radial maze discrimination task was impaired, with a significant but transient increase in both working and reference memory errors. Passive avoidance acquisition and retention were not significantly affected, although conclusions concerning the utility of this task must be reserved because of variability in the behavior of the sham-operated rats. Morris maze spatial navigation (place learning) and open-field activity were insensitive to treatment group. These functional results are consistent with the observed histological injury and what is known about hippocampal injury and behavior, and they provide further guidance for the development of neurological assays appropriate for discriminating outcome from forebrain ischemia in rats.
Details
- Title: Subtitle
- Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats
- Creators
- Thomas X Gionet - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United StatesJennifer D Thomas - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United StatesDavid S Warner - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United StatesCharles R Goodlett - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United StatesEdward A Wasserman - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United StatesJames R West - Univ. Iowa, dep. anesthesia, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.22(8), pp.1040-1047
- DOI
- 10.1161/01.STR.22.8.1040
- PMID
- 1866751
- NLM abbreviation
- Stroke
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- Language
- English
- Date published
- 1991
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070485102771
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