Journal article
Forebrain-mediated adaptations to myocardial infarction in the rat
American journal of physiology. Heart and circulatory physiology, Vol.282(5), pp.H1898-H1906
05/01/2002
DOI: 10.1152/ajpheart.00488.2001
PMID: 11959657
Abstract
Recent studies suggest that the forebrain contributes to the circulatory derangements leading to heart failure after myocardial injury. We tested that hypothesis by examining the effect of myocardial infarction (MI) or sham MI (MI-s) on neurohumoral regulation in rats with prior anteroventral (AV) third ventricle lesion (AV3V-x) or sham lesion (AV3V-s). AV3V-s/MI rats had higher sodium intake, lower urine volume, and lower urinary sodium excretion than AV3V-s/MI-s rats. AV3V-x/MI rats had lower sodium intake and higher urine volume than AV3V-s/MI or AV3V-s/MI-s rats and urinary sodium excretion comparable to AV3V-s/MI-s rats. AV3V-x had no effect on baseline plasma renin activity (PRA). One week after MI, PRA had increased in AV3V-s but decreased in AV3V-x rats. AV3V-x reduced renal sympathetic nerve activity in MI and MI-s rats. AV3V-x improved baroreflex function in MI rats but diminished it in MI-s rats. Survival beyond 2 wk was lower in the AV3V-x/MI rats than in all other groups. These results confirm a critical role for the forebrain in the neurohumoral adjustments to MI.
Details
- Title: Subtitle
- Forebrain-mediated adaptations to myocardial infarction in the rat
- Creators
- Joseph Francis - Internal Medicine andShun-Guang Wei - Internal Medicine andRobert M Weiss - Department of Veterans Affairs Medical Center and Departments of, Internal Medicine andTerry Beltz - Psychology, University of Iowa, Iowa City, Iowa 52242Alan Kim Johnson - Psychology, University of Iowa, Iowa City, Iowa 52242Robert B Felder - Department of Veterans Affairs Medical Center and Departments of, Internal Medicine and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.282(5), pp.H1898-H1906
- DOI
- 10.1152/ajpheart.00488.2001
- PMID
- 11959657
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 05/01/2002
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984065498902771
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