Journal article
Formation of Vegetations during Infective Endocarditis Excludes Binding of Bacterial-Specific Host Antibodies to Enterococcus faecalis
The Journal of infectious diseases, Vol.185(7), pp.994-997
04/01/2002
DOI: 10.1086/339604
PMID: 11920326
Abstract
Infectious endocarditis is a microbial infection of the endothelial lining of the heart that typically occurs on damaged or prosthetic heart valves. The characteristic lesion seen with infective endocarditis, termed "the vegetation," is composed of bacteria surrounded by a platelet/fibrin layer attached to the underlying endothelium. The vegetation has long been believed to exclude or hinder host defenses from clearing bacteria, although formal demonstration of mechanisms by which this occurs are lacking. This study investigated the ability of the vegetation to exclude host antibodies specific for the bacterial surface protein aggregation substance in vivo during experimental endocarditis caused by Enterococcus faecalis. The results demonstrate that, once the vegetation encloses bacteria, they are no longer accessible to high-titer bacterial-specific host antibodies, establishing a mechanism by which the vegetation functions to protect the bacteria from the humoral immune response.
Details
- Title: Subtitle
- Formation of Vegetations during Infective Endocarditis Excludes Binding of Bacterial-Specific Host Antibodies to Enterococcus faecalis
- Creators
- John K McCormick - Department of Microbiology, University of Minnesota Medical School, MinneapolisTimothy J Tripp - Department of Microbiology, University of Minnesota Medical School, MinneapolisGary M Dunny - Department of Microbiology, University of Minnesota Medical School, MinneapolisPatrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.185(7), pp.994-997
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/339604
- PMID
- 11920326
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 04/01/2002
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002395602771
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