Journal article
Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
Genes & development, Vol.15(19), pp.2533-2545
10/01/2001
DOI: 10.1101/gad.921501
PMCID: PMC312792
PMID: 11581159
Abstract
Brainstem visceral sensory and (nor)adrenergic neurons play crucial roles in modulating cardiovascular and respiratory functions. The origins and formation of these neurons are poorly understood. Here we show that these two classes of neurons are derived from
Mash1
-positive precursor cells, and can be prospectively identified by combinatorial expression of two homeobox genes,
Rnx
and
Phox2
(
Phox2a
or
Phox2b
). It was previously shown that
Rnx
-deficient mice die from respiratory failure. Here we show that Rnx function is required for formation of first-order relay visceral sensory neurons in the brainstem. In addition, as in
Phox2b
-deficient mice, the development of most (nor)adrenergic centers is compromised in
Rnx
mutants. We also provide genetic evidence to show that Rnx and Phox2 proteins may function independently to specify the (nor)adrenergic phenotype. Our studies reveal a surprising ontogenetic relationship between relay visceral sensory and (nor)adrenergic neurons, and suggest that it may be a common theme in the developing nervous system that the same set of transcriptional regulators is associated with formation of multiple components within a neuronal network.
Details
- Title: Subtitle
- Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
- Creators
- Ying Qian - The Dana-Farber Cancer Institute andBernd Fritzsch - The Dana-Farber Cancer Institute andSenji Shirasawa - The Dana-Farber Cancer Institute andChih-Li Chen - The Dana-Farber Cancer Institute andYoojin Choi - The Dana-Farber Cancer Institute andQiufu Ma - The Dana-Farber Cancer Institute and
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.15(19), pp.2533-2545
- DOI
- 10.1101/gad.921501
- PMID
- 11581159
- PMCID
- PMC312792
- NLM abbreviation
- Genes Dev
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Publisher
- Cold Spring Harbor Laboratory Press
- Language
- English
- Date published
- 10/01/2001
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070430502771
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