Journal article
Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22
Journal of analytical toxicology, Vol.38(8), pp.559-562
10/2014
DOI: 10.1093/jat/bku048
PMCID: PMC4334789
PMID: 24876364
Abstract
In January 2014, the US government temporarily designated 5F-PB-22, along with three other synthetic cannabinoids (AB-FUBINACA, ADB-PINACA and PB-22), into Schedule I. Over the course of a 4-month time period (July-October 2013), our laboratory quantitatively identified 5F-PB-22 in specimens obtained from four postmortem cases. We describe the four cases, to include pertinent autopsy findings and decedent histories, together with quantitative results for 5F-PB-22 determined in postmortem blood and antemortem serum. Samples were prepared via a liquid-liquid extraction at pH 10.2 into hexane : ethyl acetate. Instrumental analysis was achieved with liquid chromatography coupled with electrospray ionization tandem mass spectrometry operating in multiple reaction monitoring mode. Two ion transitions were monitored for the analyte of interest, and one ion transition was monitored for the internal standard. The observed concentration range of 5F-PB-22 is 1.1-1.5 ng/mL for three postmortem blood specimens and one antemortem serum specimen. Three of the decedents experienced abrupt, sudden death; however, one decedent expired after a rapidly deteriorating hospital course.
Details
- Title: Subtitle
- Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22
- Creators
- George Behonick - AIT Laboratories, Indianapolis, IN 46241, USA gbehonick@aitlabs.comKevin G Shanks - AIT Laboratories, Indianapolis, IN 46241, USADennis J Firchau - University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAGagan Mathur - University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USACharles F Lynch - University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMarcus Nashelsky - University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USADavid J Jaskierny - Physicians Laboratory PC, Omaha, NE 68117, USAChady Meroueh - Department of Pathology and Laboratory Medicine, Mercy Medical Center-North Iowa, Mason City, IA 50401, USA
- Resource Type
- Journal article
- Publication Details
- Journal of analytical toxicology, Vol.38(8), pp.559-562
- Publisher
- England
- DOI
- 10.1093/jat/bku048
- PMID
- 24876364
- PMCID
- PMC4334789
- ISSN
- 0146-4760
- eISSN
- 1945-2403
- Grant note
- P30 ES005605 / NIEHS NIH HHS
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983995057002771
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