Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen

Stacey S Choi; Robert J Zawadzki; Mark A Greiner; John S Werner; John L Keltner

doi:10.1097/WNO.0b013e318175c6f5

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Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen

Journal article

Open access

Peer reviewed

Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen

Stacey S Choi, Robert J Zawadzki, Mark A Greiner, John S Werner and John L Keltner

Journal of neuro-ophthalmology, Vol.28(2), pp.120-125

06/2008

DOI: 10.1097/WNO.0b013e318175c6f5

PMCID: PMC2584152

PMID: 18562844

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Abstract

New technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic disc drusen. Using Stratus and Fourier domain (FD) optical coherence tomography (OCT) and adaptive optics (AO) through a flood-illuminated fundus camera, we studied the retinas of a patient with long-standing optic disc drusen and acute visual loss at high altitude attributed to ischemic optic neuropathy. Stratus OCT and FD-OCT confirmed severe thinning of the retinal nerve fiber layer (RNFL). FD-OCT revealed disturbances in the photoreceptor layer heretofore not described in optic disc drusen patients. AO confirmed the FD-OCT findings in the photoreceptor layer and also showed reduced cone density at retinal locations associated with reduced visual sensitivity. Based on this study, changes occur not only in the RNFL but also in the photoreceptor layer in optic nerve drusen complicated by ischemic optic neuropathy. This is the first reported application of FD-OCT and the AO to this condition. Such new imaging technology may in the future allow monitoring of disease progression more precisely and accurately.

Visual Fields - physiology

Cerebrovascular Circulation - physiology

Vision, Low - pathology

Humans

Male

Retinal Cone Photoreceptor Cells - physiopathology

Optic Atrophy - pathology

Retinal Ganglion Cells - pathology

Optic Neuropathy, Ischemic - etiology

Fourier Analysis

Optic Atrophy - etiology

Retinal Cone Photoreceptor Cells - pathology

Adult

Optics and Photonics - instrumentation

Photoreceptor Cells - pathology

Vision, Low - physiopathology

Optic Disk Drusen - physiopathology

Optic Disk Drusen - complications

Optic Neuropathy, Ischemic - physiopathology

Optic Atrophy - physiopathology

Hypoxia - complications

Tomography, Optical Coherence - methods

Vision, Low - etiology

Optic Neuropathy, Ischemic - pathology

Retinal Artery - physiopathology

Optic Disk Drusen - pathology

Altitude Sickness - complications

Tomography, Optical Coherence - instrumentation

Details

Title: Subtitle: Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen
Creators: Stacey S Choi - Department of Ophthalmology and Vision Science, University of California at Davis, Sacramento, California 95817, USA
Robert J Zawadzki
Mark A Greiner
John S Werner
John L Keltner
Resource Type: Journal article
Publication Details: Journal of neuro-ophthalmology, Vol.28(2), pp.120-125
DOI: 10.1097/WNO.0b013e318175c6f5
PMID: 18562844
PMCID: PMC2584152
NLM abbreviation: J Neuroophthalmol
ISSN: 1070-8022
eISSN: 1536-5166
Publisher: United States
Grant note: R01 EY014743 / NEI NIH HHS EY 014743 / NEI NIH HHS R01 EY014743-06 / NEI NIH HHS
Language: English
Date published: 06/2008
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980075502771

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