Fractionated Stereotactic Radiotherapy Compared to Stereotactic Radiosurgery for Vestibular Schwannoma in Patients with Type 2 Neurofibromatosis

Geovanne Pedro Mauro; Leila Maria Da Róz; Vinicius de Carvalho Gico; Eduardo Weltman; Evandro Cesar De Souza; Eberval Gadelha Figueiredo; Manoel Jacobsen Teixeira

doi:10.1016/j.wneu.2023.08.110

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Fractionated Stereotactic Radiotherapy Compared to Stereotactic Radiosurgery for Vestibular Schwannoma in Patients with Type 2 Neurofibromatosis

Journal article

Peer reviewed

Fractionated Stereotactic Radiotherapy Compared to Stereotactic Radiosurgery for Vestibular Schwannoma in Patients with Type 2 Neurofibromatosis

Geovanne Pedro Mauro, Leila Maria Da Róz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar De Souza, Eberval Gadelha Figueiredo and Manoel Jacobsen Teixeira

World neurosurgery, Vol.179, pp.e416-e420

11/2023

DOI: 10.1016/j.wneu.2023.08.110

PMID: 37657590

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Abstract

The use of radiotherapy (RT) for the treatment of vestibulocochlear schwannomas is standard in patients with type 2 neurofibromatosis (NF2). In the general population, fractionated RT (FRT) can achieve good results compared to single-dose radiosurgery (SRS). We aimed to assess whether this is true for NF2 patients as well. This retrospective cohort study included 34 patients and 54 lesions treated between 2010 and 2023 in a single university hospital. Thirty-four patient charts were assessed. The median follow-up was 62.6 months (range, 7.1-135.8 months). Lesion size (median larger diameter, 2.5 cm) was correlated with the use of FRT (P > 0.001). Younger age also was correlated with FRT (P = 0.006). Median overall survival and progression-free survival (PFS) were not reached. The overall control rate was 76.5%, and the mean PFS was 49.8 months, compared with . 90.5% and 57.2 months, respectively, for SRS and 66.7% and 44.9 months, respectively, for FRT. There were no differences between the 2 groups in hearing loss, tinnitus, and facial palsy. In the NF2 population, FRT may yield worse control rates than SRS. Whenever possible, it is preferable to not fractionate treatment for these patients. Nevertheless, the FRT results were still good. More and larger prospective trials are warranted.

Follow-Up Studies

Humans

Neurofibromatosis 2 - complications

Neurofibromatosis 2 - radiotherapy

Neuroma, Acoustic - complications

Neuroma, Acoustic - radiotherapy

Neuroma, Acoustic - surgery

Prospective Studies

Radiosurgery - methods

Retrospective Studies

Treatment Outcome

Details

Title: Subtitle: Fractionated Stereotactic Radiotherapy Compared to Stereotactic Radiosurgery for Vestibular Schwannoma in Patients with Type 2 Neurofibromatosis
Creators: Geovanne Pedro Mauro - Universidade de São Paulo
Leila Maria Da Róz - Universidade de São Paulo
Vinicius de Carvalho Gico - Instituto do Câncer do Estado de São Paulo
Eduardo Weltman - Universidade de São Paulo
Evandro Cesar De Souza - Universidade de São Paulo
Eberval Gadelha Figueiredo - Universidade de São Paulo
Manoel Jacobsen Teixeira - Universidade de São Paulo
Resource Type: Journal article
Publication Details: World neurosurgery, Vol.179, pp.e416-e420
DOI: 10.1016/j.wneu.2023.08.110
PMID: 37657590
NLM abbreviation: World Neurosurg
ISSN: 1878-8750
eISSN: 1878-8769
Language: English
Date published: 11/2023
Academic Unit: Radiation Oncology
Record Identifier: 9984914146002771

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