Journal article
Frailty and health-related quality of life among older people living with HIV pre- and post-COVID-19 pandemic onset: A cross-sectional study
The Brazilian journal of infectious diseases, Vol.28(1), pp.103723-103723
01/01/2024
DOI: 10.1016/j.bjid.2024.103723
PMCID: PMC10904252
PMID: 38369295
Abstract
Introduction: Antiretroviral therapy increased the survival and life expectancy of People living With HIV (PWH). Frailty-related syndromes among older PWH (aged 50+ years) may affect their Health-related Quality of Life (HQoL). Additionally, the COVID-19 pandemic has impacted health-related outcomes. This study aimed to estimate the prevalence of frailty and pre-frailty among older PWH, and to explore associations of HQoL with the study assessment period and frailty status. Methods: Cross-sectional study conducted pre- (23 -Mar -2019 to 5 -Mar -2020) and postCOVID-19 pandemic onset (23 -Jun -2021 to 5 -May -2022), among older PWH at INI-Fiocruz, the largest cohort of PWH in Rio de Janeiro, Brazil. We measured frailty using Fried assessment, consisting of five domains: unintentional weight loss; self-reported exhaustion, weakness, slow walking speed, low physical activity. HQoL was assessed using the ACTG SF -21, which contains 21 questions divided into 8 domains. We used Chi -Square test, Fisher's exact test, Kruskal-Wallis and ranksum test for comparisons. Results: We included 250 older PWH: 109 (43.6 %) pre- and 141 (56.4 %) post-COVID-19 pandemic onset. Median age was 60 -years (IQR: 55-64). Most self-identified as cisgender men 152 (60.8 %), Pardo/Black 146 (58.4 %), with completed secondary education or less 181 (72.7 %) and low income 132 (52.8 %). Overall, prevalence of frailty and pre-frailty were 9.2 % (95 % CI: 8.1-10.3) and 61.6 % (95 % CI: 54.0-69.2). Prevalence of frailty in the pre- and posCOVID-19 pandemic periods were 7.3 % and 10.6 % (p = 0.66). HQoL scores were lower among participants with frailty compared to those with non-frailty and pre-frailty in all eight domains, and among those included in the post-COVID-19 compared to pre-COVID19 period for four domains. Conclusions: We observed low prevalence of frailty, but high prevalence of pre-frailty among older PWH. Frailty status did not differ according to the COVID-19 assessment period. Assessment of frailty and HQoL should be incorporated in clinical practice for older PWH. Programs to reverse or prevent frailty should be implemented within the public health system. (c) 2024 Sociedade Brasileira de Infectologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Details
- Title: Subtitle
- Frailty and health-related quality of life among older people living with HIV pre- and post-COVID-19 pandemic onset: A cross-sectional study
- Creators
- Thiago S. Torres - Fundação Oswaldo CruzJovanice S. Jesus - Fundação Oswaldo CruzDaniel Arabe - Fundação Oswaldo CruzLusiele Guaraldo - Fundação Oswaldo CruzFabiao A. Meque - Fundação Oswaldo CruzFlavia Serrao Lessa - Fundação Oswaldo CruzLivia Dumont Facchinetti - Fundação Oswaldo CruzRita Estrela - Fundação Oswaldo CruzValdilea G. Veloso - Fundação Oswaldo CruzBeatriz Grinsztejn - Fundação Oswaldo CruzSandra W. Cardoso - Fundação Oswaldo Cruz
- Resource Type
- Journal article
- Publication Details
- The Brazilian journal of infectious diseases, Vol.28(1), pp.103723-103723
- DOI
- 10.1016/j.bjid.2024.103723
- PMID
- 38369295
- PMCID
- PMC10904252
- NLM abbreviation
- Braz J Infect Dis
- ISSN
- 1413-8670
- eISSN
- 1678-4391
- Publisher
- Elsevier
- Number of pages
- 9
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984771653102771
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