Journal article
Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort
Aging (Albany, NY.), Vol.17(7), pp.1590-1623
07/30/2025
DOI: 10.18632/aging.206275
PMCID: PMC12339021
PMID: 40622758
Abstract
Frailty is associated with respiratory exacerbations and mortality in individuals with Chronic Obstructive Pulmonary Disease (COPD). Among those with a smoking history and normal spirometry, frailty's association with respiratory outcomes is less defined. COPDGene is a cohort study of individuals aged 45-80 with a minimum 10 pack-year smoking history. A modified Fried Frailty Phenotype was performed at 10-year follow-up; participants were categorized as frail, prefrail, or robust. Primary outcomes were respiratory exacerbations, epigenetic pace of aging, and all-cause mortality. Among 2665 participants, 401 (15%) were frail and 1352 (51%) were prefrail. Adjusting for smoking and lung function, frailty was associated with prospective respiratory exacerbation rate (IRR 3.4, 95% CI 2.4-4.8), severe exacerbations (OR 2.8(1.8-4.2)), and frequent exacerbations (OR 5.5(3.2-9.3)). Prefrailty was also associated with exacerbation outcomes (rate IRR 1.8(1.4-2.3); severe OR 1.6(1.1-2.2); frequent OR 2.6(1.7-4.1)). Frailty and prefrailty were associated with increased all-cause mortality (AHR: frailty 4.5(2.4-8.5); prefrailty 2.5(1.5-4.2)). All frailty (and most prefrailty) findings persisted in those with normal spirometry. Baseline DunedinPACE of aging was associated with prospective frailty at 10-year follow-up. Frailty associated with respiratory exacerbations and mortality; findings persisted among individuals with normal spirometry, highlighting the relevance of evaluating for frailty in people with a history of smoking.
Details
- Title: Subtitle
- Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort
- Creators
- Eleanor Kate Phillips - Brigham and Women's HospitalYichen Huang - Brigham and Women's HospitalElizabeth Regan - National Jewish HealthBarry Make - National Jewish HealthMatthew Strand - National Jewish HealthAbebaw Mengistu Yohannes - University of Alabama at BirminghamNicola A Hanania - Baylor College of MedicineJessica Bon - Wake Forest UniversityKarin F Hoth - University of IowaJames D Crapo - National Jewish HealthEdwin K Silverman - Harvard UniversityDawn L DeMeo - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Aging (Albany, NY.), Vol.17(7), pp.1590-1623
- DOI
- 10.18632/aging.206275
- PMID
- 40622758
- PMCID
- PMC12339021
- NLM abbreviation
- Aging (Albany NY)
- ISSN
- 1945-4589
- eISSN
- 1945-4589
- Language
- English
- Electronic publication date
- 07/03/2025
- Date published
- 07/30/2025
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984847147502771
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