Free-breathing cine imaging with motion-corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self-gating (SPARCS)

Ruixi Zhou; Yang Yang; Roshin C Mathew; John P Mugler III; Daniel S Weller; Christopher M Kramer; Abdul Haseeb Ahmed; Mathews Jacob; Michael Salerno

doi:10.1002/mrm.27763

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Free-breathing cine imaging with motion-corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self-gating (SPARCS)

Journal article

Peer reviewed

Free-breathing cine imaging with motion-corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self-gating (SPARCS)

Ruixi Zhou, Yang Yang, Roshin C Mathew, John P Mugler III, Daniel S Weller, Christopher M Kramer, Abdul Haseeb Ahmed, Mathews Jacob and Michael Salerno

Magnetic resonance in medicine, Vol.82(2), pp.706-720

08/2019

DOI: 10.1002/mrm.27763

PMCID: PMC6510595

PMID: 31006916

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https://www.ncbi.nlm.nih.gov/pmc/articles/6510595View

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Abstract

To develop a continuous-acquisition cardiac self-gated spiral pulse sequence and a respiratory motion-compensated reconstruction strategy for free-breathing cine imaging. Cine data were acquired continuously on a 3T scanner for 8 seconds per slice without ECG gating or breath-holding, using a golden-angle gradient echo spiral pulse sequence. Cardiac motion information was extracted by applying principal component analysis on the gridded 8 × 8 k-space center data. Respiratory motion was corrected by rigid registration on each heartbeat. Images were reconstructed using a low-rank and sparse (L+S) technique. This strategy was evaluated in 37 healthy subjects and 8 subjects undergoing clinical cardiac MR studies. Image quality was scored (1-5 scale) in a blinded fashion by 2 experienced cardiologists. In 13 subjects with whole-heart coverage, left ventricular ejection fraction (LVEF) from SPiral Acquisition with Respiratory correction and Cardiac Self-gating (SPARCS) was compared to that from a standard ECG-gated breath-hold balanced steady-state free precession (bSSFP) cine sequence. The self-gated signal was successfully extracted in all cases and demonstrated close agreement with the acquired ECG signal (mean bias, -0.22 ms). The mean image score across all subjects was 4.0 for reconstruction using the L+S model. There was good agreement between the LVEF derived from SPARCS and the gold-standard bSSFP technique. SPARCS successfully images cardiac function without the need for ECG gating or breath-holding. With an 8-second data acquisition per slice, whole-heart cine images with clinically acceptable spatial and temporal resolution and image quality can be acquired in <90 seconds of free-breathing acquisition.

Magnetic Resonance Imaging, Cine - methods

Cardiac-Gated Imaging Techniques - methods

Heart - physiology

Humans

Image Interpretation, Computer-Assisted - methods

Breath Holding

Respiration

Heart - diagnostic imaging

Details

Title: Subtitle: Free-breathing cine imaging with motion-corrected reconstruction at 3T using SPiral Acquisition with Respiratory correction and Cardiac Self-gating (SPARCS)
Creators: Ruixi Zhou - Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia
Yang Yang - Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York
Roshin C Mathew - Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
John P Mugler III - Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
Daniel S Weller - Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, Virginia
Christopher M Kramer - Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
Abdul Haseeb Ahmed - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa
Mathews Jacob - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa
Michael Salerno - Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine, Vol.82(2), pp.706-720
DOI: 10.1002/mrm.27763
PMID: 31006916
PMCID: PMC6510595
NLM abbreviation: Magn Reson Med
ISSN: 0740-3194
eISSN: 1522-2594
Publisher: United States
Grant note: R01 HL131919 / NHLBI NIH HHS T32 EB003841 / NIBIB NIH HHS K23 HL112910 / NHLBI NIH HHS
Language: English
Date published: 08/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984070991602771

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