Free-radical damage: a possible mechanism of laryngeal aging

Jason Diamond; Jennifer Skaggs; Jose M Manaligod

doi:10.1177/014556130208100813

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Free-radical damage: a possible mechanism of laryngeal aging

Journal article

Open access

Peer reviewed

Free-radical damage: a possible mechanism of laryngeal aging

Jason Diamond, Jennifer Skaggs and Jose M Manaligod

Ear, nose, & throat journal, Vol.81(8), pp.531-533

08/2002

DOI: 10.1177/014556130208100813

PMID: 12199170

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Abstract

We conducted a study of lipid peroxidation as a marker of age-related free-radical damage in the human larynx--the first study of its kind. A colorimetric assay for malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) was performed on extracts taken from thyroarytenoid muscle harvested from fresh cadaveric laryngeal specimens. Levels of MDA and 4-HNE were measured by spectrophotometry. Correlation studies were performed by linear regression analysis. We found that MDA levels in human thyroarytenoid muscle appeared to increase with age while 4-HNE levels showed a slight decrease with age. Our findings are consistent with those of previous studies of other organ systems and indicate that there is a need for further study of free-radical damage and the effects of aging on the human larynx and on voice production.

Malondialdehyde - metabolism

Larynx - metabolism

Oxidative Stress

Culture Techniques

Humans

Middle Aged

Linear Models

Male

Free Radicals - adverse effects

Aldehydes - metabolism

Lipid Peroxidation - physiology

Malondialdehyde - analysis

Aging - physiology

Aldehydes - analysis

Larynx - physiopathology

Sensitivity and Specificity

Aged, 80 and over

Female

Aged

Spectrophotometry

Cadaver

Details

Title: Subtitle: Free-radical damage: a possible mechanism of laryngeal aging
Creators: Jason Diamond - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospital and Clinics, 200 Hawkins Dr., Iowa City, IA 52242, USA
Jennifer Skaggs
Jose M Manaligod
Resource Type: Journal article
Publication Details: Ear, nose, & throat journal, Vol.81(8), pp.531-533
DOI: 10.1177/014556130208100813
PMID: 12199170
NLM abbreviation: Ear Nose Throat J
ISSN: 0145-5613
eISSN: 1942-7522
Publisher: United States
Language: English
Date published: 08/2002
Academic Unit: Stead Family Department of Pediatrics; Otolaryngology
Record Identifier: 9984006409602771

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