Frequency Content of Cartilage Impact Force Signal Reflects Acute Histologic Structural Damage

Anneliese D Heiner; James A Martin; Todd O McKinley; Jessica E Goetz; Daniel R Thedens; Thomas D Brown

doi:10.1177/1947603511430706

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Frequency Content of Cartilage Impact Force Signal Reflects Acute Histologic Structural Damage

Journal article

Open access

Peer reviewed

Frequency Content of Cartilage Impact Force Signal Reflects Acute Histologic Structural Damage

Anneliese D Heiner, James A Martin, Todd O McKinley, Jessica E Goetz, Daniel R Thedens and Thomas D Brown

Cartilage, Vol.3(4), pp.314-322

10/2012

DOI: 10.1177/1947603511430706

PMCID: PMC3760429

PMID: 24015324

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https://doi.org/10.1177/1947603511430706View

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Abstract

Objective: The objective of this study was to determine if acute cartilage impact damage could be predicted by a quantification of the frequency content of the impact force signal. Design: Osteochondral specimens excised from bovine lateral tibial plateaus were impacted with one of six impact energies. Each impact force signal underwent frequency analysis, with the amount of higher-frequency content (percent of frequency spectrum above 1 KHz) being registered. Specimens were histologically evaluated to assess acute structural damage (articular surface cracking and cartilage crushing) resulting from the impact. Results: Acute histologic structural damage to the cartilage had higher concordance with the high-frequency content measure than with other mechanical impact measures (delivered impact energy, impact maximum stress, and impact maximum stress rate of change). Conclusions: This result suggests that the frequency content of an impact force signal, specifically the proportion of higher-frequency components, can be used as a quick surrogate measure for acute structural cartilage injury. Taking advantage of this relationship could reduce the time and expense of histological processing needed to morphologically assess cartilage damage, especially for purposes of initial screening when evaluating new impaction protocols.

Histology

articular cartilage

impact testing

posttraumatic osteoarthritis

impact injury

Details

Title: Subtitle: Frequency Content of Cartilage Impact Force Signal Reflects Acute Histologic Structural Damage
Creators: Anneliese D Heiner - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
James A Martin - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
Todd O McKinley - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
Jessica E Goetz - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
Daniel R Thedens - Department of Radiology, University of Iowa, Iowa City, IA, USA
Thomas D Brown - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Cartilage, Vol.3(4), pp.314-322
DOI: 10.1177/1947603511430706
PMID: 24015324
PMCID: PMC3760429
NLM abbreviation: Cartilage
ISSN: 1947-6035
eISSN: 1947-6043
Publisher: SAGE Publications; Sage CA: Los Angeles, CA
Language: English
Date published: 10/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation
Record Identifier: 9984040237102771

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