Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria

Helio S Sader; Mariana Castanheira; Jennifer M Streit; Cecilia G Carvalhaes; Rodrigo E Mendes

doi:10.1016/j.diagmicrobio.2020.115108

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Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria

Journal article

Peer reviewed

Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria

Helio S Sader, Mariana Castanheira, Jennifer M Streit, Cecilia G Carvalhaes and Rodrigo E Mendes

Diagnostic microbiology and infectious disease, Vol.98(2), pp.115108-115108

10/2020

DOI: 10.1016/j.diagmicrobio.2020.115108

PMID: 32640386

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Abstract

Studies evaluating large series of pediatric patients with bloodstream infections (BSIs) are scarce. We evaluated the frequency and antimicrobial susceptibility of organisms isolated from pediatric patients with BSI and therapeutic options for BSI caused by multidrug-resistant (MDR) organisms. A total of 2423 organisms were consecutively collected from 33 US medical centers between 2014 and 2018, and susceptibility was tested by reference broth microdilution methods. Isolates with an extended-spectrum β-lactamase phenotype were screened for β-lactamase genes. Overall, 40.2% of organisms were Gram-negative bacteria, 57.0% Gram-positives, and 2.8% Candida spp. The 5 most common organisms were Staphylococcus aureus (26.0%), Escherichia coli (13.0%), coagulase-negative staphylococci (8.3%), Enterococcus faecalis (7.1%), and Klebsiella pneumoniae (6.9%). Among S. aureus, 26.0% were oxacillin-resistant and 99.8% were susceptible to ceftaroline (MIC , 0.25/0.5 mg/L). Enterobacterales and Pseudomonas aeruginosa isolates combined represented >85% of Gram-negative bacteria, and all isolates (100.0%) were susceptible to ceftazidime-avibactam.

Adolescent

Anti-Infective Agents - pharmacology

Azabicyclo Compounds - pharmacology

Bacteria - drug effects

Bacteria - isolation & purification

Bacterial Proteins

beta-Lactamases - genetics

beta-Lactamases - metabolism

Candida - drug effects

Candida - isolation & purification

Ceftazidime - pharmacology

Cephalosporins - pharmacology

Child

Child, Preschool

Drug Combinations

Drug Resistance, Multiple, Bacterial

Humans

Infant

Microbial Sensitivity Tests

Oxacillin - pharmacology

Sepsis - drug therapy

Sepsis - microbiology

United States - epidemiology

Details

Title: Subtitle: Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria
Creators: Helio S Sader - JMI Laboratories
Mariana Castanheira - JMI Laboratories
Jennifer M Streit - JMI Laboratories
Cecilia G Carvalhaes - JMI Laboratories
Rodrigo E Mendes - JMI Laboratories
Resource Type: Journal article
Publication Details: Diagnostic microbiology and infectious disease, Vol.98(2), pp.115108-115108
DOI: 10.1016/j.diagmicrobio.2020.115108
PMID: 32640386
ISSN: 0732-8893
eISSN: 1879-0070
Grant note: DOI: 10.13039/100007819, name: Allergan
Language: English
Date published: 10/2020
Academic Unit: Pathology
Record Identifier: 9984183996202771

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