Journal article
Frequency and outcome of cerebral venous thrombosis attributed to oral contraceptive pills
Neurology Asia, Vol.29(3), pp.619-627
09/01/2024
DOI: 10.54029/2024xza
Abstract
Background: Oral contraceptive (OCP) use is a significant risk factor for cerebral venous thrombosis (CVT). There is limited research on its association with CVT development in Islamic countries. Therefore, our study aimed to assess the risk of different OCPs in developing CVT and their prognosis. Methods: This is an observational retrospective single-center cohort study that included CVT patients between March 2018 and March 2021. All CVT participants were registered in the organized registry system (CVT registry code: 9001013381) at the Neurology Research Center of Shiraz University of Medical Science. Univariate analysis and multivariable binary logistic regression modeling were applied to determine the associated factors leading to poor outcome. Results: A total of 204 patients (139 women, 65 men) were enrolled in the study. Seventy-four females (53.25% of total female patients) used OCPs, with second-generation OCPs being the most commonly used type (70%). OCP consumption was associated with a lower mortality rate (P=0.004, aOR=11.732) and a better 3-month follow-up outcome (p=0.001, aOR=9.882) than their female counterparts who did not use OCPs. The duration and generation of OCPs did not affect the follow-up outcome (P=0.148, P=0.428, respectively) or mortality (P=0.555, P=0.569, respectively). In multivariable analysis, the use of OCPs was a predictor of a favorable 3-month follow-up outcome in females (aOR =4.423, 95% CI: 0.423-46.248). Conclusion: These results suggest that OCPs may have a positive impact on the prognosis of CVT in women. However, further research is required to understand the underlying mechanisms and validate these findings.
Details
- Title: Subtitle
- Frequency and outcome of cerebral venous thrombosis attributed to oral contraceptive pills
- Creators
- Maryam Vasaghi-Gharamaleki - Shiraz UniversityEtrat Hooshmandi - Shiraz UniversityMaryam Habibagahi - Shiraz UniversityMohammad Javad Gholamzadeh - Shiraz UniversityHossein Molavi Vardanjani - Shiraz UniversityNima Fadakar - Shiraz UniversityVahid Reza Ostovan - Shiraz UniversityAbbas Rahimi-Jaberi - Shiraz UniversityNahid Ashjazadeh - Shiraz UniversityPeyman PetramfarMaryam Poursadeghfard - Shiraz UniversitySadegh Izadi - Shiraz UniversityMasoumeh Nazeri - Shiraz UniversityHanieh BazrafshanZahra Bahrami - Shiraz UniversitySedigheh Karimlu - Shiraz UniversityMahnaz Bayat - Shiraz UniversityMohammad Saied Salehi - Shiraz UniversityBanafsheh Shakibajahromi - Shiraz UniversityYangyang Xiao - Canberra HospitalVarnika Sharma - Canberra HospitalRoham GoudarziAnahid Safari - Shiraz UniversityAnita van de Munckhof - University of AmsterdamJonathan M. Coutinho - University of AmsterdamAfshin Borhani-Haghighi - Shiraz University
- Resource Type
- Journal article
- Publication Details
- Neurology Asia, Vol.29(3), pp.619-627
- DOI
- 10.54029/2024xza
- ISSN
- 1823-6138
- Publisher
- Asean Neurological Assoc
- Number of pages
- 9
- Grant note
- 19434 / Office of Vice Chancellor for Research at Shiraz University of Medical Sciences; Shiraz University of Medical Science
- Language
- English
- Date published
- 09/01/2024
- Academic Unit
- Neurology
- Record Identifier
- 9985014708302771
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