Journal article
Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates
Antimicrobial agents and chemotherapy, Vol.58(1), pp.577-580
2014
DOI: 10.1128/AAC.01674-13
PMCID: PMC3910756
PMID: 24126582
Abstract
Among 119 echinocandin non-wild-type (non-WT) Candida glabrata strains from two global surveys, mutations in fks hot spots (HSs) were detected in 28 (from 7 countries and 8 U.S. states): 24 strains (85.7%) had non-WT MICs for micafungin, 22 (78.6%) for anidulafungin, and 25 (89.3%) for caspofungin. The most common FKS substitutions among non-WT strains were at positions F659 (n = 7) and S663 (n = 7). Three isolates displaying WT MIC results had F625Y, L630I, and D632Y substitutions or non-HS mutations. Mutations that have been reported to decrease the echinocandin binding to the 1,3-β-d-glucan synthase were categorized as resistant by applying the new CLSI breakpoint criteria for all three echinocandins.
Details
- Title: Subtitle
- Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates
- Creators
- Mariana Castanheira - JMI Laboratories, North Liberty, Iowa, USALeah N WoosleyShawn A MesserDaniel J DiekemaRonald N JonesMichael A Pfaller
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.58(1), pp.577-580
- Publisher
- United States
- DOI
- 10.1128/AAC.01674-13
- PMID
- 24126582
- PMCID
- PMC3910756
- ISSN
- 1098-6596
- eISSN
- 1098-6596
- Language
- English
- Date published
- 2014
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986271202771
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