Journal article
Frequency response characteristics of sympathetically mediated vasomotor waves in humans
American journal of physiology. Heart and circulatory physiology, Vol.274(4), pp.H1277-H1283
04/01/1998
DOI: 10.1152/ajpheart.1998.274.4.H1277
PMID: 9575932
Abstract
In a recent study, we demonstrated that transmission from peripheral sympathetic nerves to vascular smooth muscles is strongest in the frequency band from 0.2 to 0.5 Hz in conscious rats. In contrast, sympathetic modulation of vasomotor tone in humans is suggested to be reflected in the power spectrum of arterial blood pressure in a frequency range centered around ∼0.1 Hz. Therefore, we addressed whether frequency response characteristics of sympathetic transmission from peripheral sympathetic nerves to vascular smooth muscles in humans differ from those in rats. In 12 male subjects, skin-sympathetic fibers of the left median nerve were electrically stimulated via microneurography needles with stimulation frequencies ranging from 0.01 to 0.5 Hz. Simultaneously, blood flow in the innervated skin area at the palm of the ipsilateral hand was recorded by a laser-Doppler device. The skin blood flow in the same area of the contralateral hand was recorded as a control. Median nerve stimulation produced transient decreases in skin blood flow in the ipsilateral hand. At frequencies ranging from 0.025 to 0.10 Hz, median nerve stimulation evoked high-power peaks at the same frequencies in the skin blood flow power spectra of the ipsilateral but not of the contralateral hand. The greatest responses were found in the frequency range from 0.075 to 0.10 Hz. Therefore, these data indicate that the transmission from peripheral sympathetic nerves to cutaneous vascular smooth muscles in humans is slower than in rats. In addition, the frequency range believed to be most important in sympathetic modulation of vasomotor activity in humans corresponds to the frequency band of the greatest response of cutaneous vascular smooth muscle contraction to sympathetic nerve stimulation.
Details
- Title: Subtitle
- Frequency response characteristics of sympathetically mediated vasomotor waves in humans
- Creators
- Harald M Stauss - Departments of Exercise Science,, Department of Physiology, Humboldt University Charité, 10117 Berlin, GermanyErling A Anderson - Anesthesia, andWilliam G Haynes - Internal Medicine, University of Iowa, Iowa City, Iowa 52242; andKevin C Kregel - Departments of Exercise Science
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.274(4), pp.H1277-H1283
- DOI
- 10.1152/ajpheart.1998.274.4.H1277
- PMID
- 9575932
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 04/01/1998
- Academic Unit
- Radiation Oncology; Provost Office Administration; Health and Human Physiology
- Record Identifier
- 9984213308902771
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