Journal article
Friend leukemia cells: Relationship between differentiation, clonogenicity and malignancy
Cell differentiation, Vol.7(1), pp.1-10
1978
DOI: 10.1016/0045-6039(78)90002-7
PMID: 566165
Abstract
Friend leukemia cells were cultured in vitro in the presence or absence of agents which induce erythroid differentiation. The cultures were harvested and the degree of differentiation determined. Clonogenicity of the cells in vitro and malignancy in vivo were determined as well. There was an inverse exponential relationship between the degree of differentiation and the clonogenicity of the culture. Differentiation was also associated with a modest decline in malignancy. Of interest was the observation that bromodeoxy-uridine inhibited the biochemical manifestations of erythroid differentiation, but did not prevent the decline in clonogenicity which accompanied differentiation.
Details
- Title: Subtitle
- Friend leukemia cells: Relationship between differentiation, clonogenicity and malignancy
- Creators
- Harvey D. Preisler - Roswell Park Cancer InstituteGregory Christoff - Roswell Park Cancer InstitutePeter Reese - Roswell Park Cancer InstitutePaul Pavelic - Roswell Park Cancer InstituteYoucef Rustum - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Cell differentiation, Vol.7(1), pp.1-10
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0045-6039(78)90002-7
- PMID
- 566165
- ISSN
- 0045-6039
- Language
- English
- Date published
- 1978
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359920302771
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