Journal article
From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health
The Journal of neuroscience, Vol.41(5), pp.873-882
02/03/2021
DOI: 10.1523/JNEUROSCI.1649-20.2020
PMCID: PMC7880276
PMID: 33446519
Abstract
A central goal of neuroscience research is to understand how experiences modify brain circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit activity engages gene regulatory mechanisms within each cell. This activity-dependent gene expression is governed, in part, by epigenetic processes that can produce persistent changes in both neural circuits and the epigenome itself. The complex interplay between circuit activity and neuronal gene regulation is vital to learning and memory, and, when disrupted, is linked to debilitating psychiatric conditions, such as substance use disorder. To develop clinical treatments, it is paramount to advance our understanding of how neural circuits and the epigenome cooperate to produce behavioral adaptation. Here, we discuss how new genetic tools, used to manipulate neural circuits and chromatin, have enabled the discovery of epigenetic processes that bring about long-lasting changes in behavior relevant to mental health and disease.
Details
- Title: Subtitle
- From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health
- Creators
- Philipp Mews - Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10129 philipp.mews@mssm.eduErin S Calipari - Departments of Pharmacology, Molecular Physiology and Biophysics, Psychiatry and Behavioral Sciences; Vanderbilt Center for Addiction Research; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37323Jeremy Day - Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294Mary Kay Lobo - Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201Timothy Bredy - Queensland Brain Institute, University of Queensland, Brisbane, 4072, AustraliaTed Abel - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.41(5), pp.873-882
- DOI
- 10.1523/JNEUROSCI.1649-20.2020
- PMID
- 33446519
- PMCID
- PMC7880276
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- United States
- Grant note
- DP1 DA039650 / NIDA NIH HHS R00 DA042111 / NIDA NIH HHS R01 MH114990 / NIMH NIH HHS P01 DA047233 / NIDA NIH HHS R01 MH087463 / NIMH NIH HHS K99 AA027839 / NIAAA NIH HHS R00 DA034681 / NIDA NIH HHS R01 DA038613 / NIDA NIH HHS K99 DA042111 / NIDA NIH HHS DP1 DA048931 / NIDA NIH HHS R01 DA047843 / NIDA NIH HHS K99 DA034681 / NIDA NIH HHS
- Language
- English
- Date published
- 02/03/2021
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070617302771
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