Journal article
From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling
Frontiers in pediatrics, Vol.4, p.80
08/17/2016
DOI: 10.3389/fped.2016.00080
PMCID: PMC4988064
PMID: 27583245
Abstract
The field of stem cell biology, cell therapy, and regenerative medicine has expanded almost exponentially, in the last decade. Clinical trials are evaluating the potential therapeutic use of stem cells in many adult and pediatric lung diseases with vascular component, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), or pulmonary arterial hypertension (PAH). Extensive research activity is exploring the lung resident and circulating progenitor cells and their contribution to vascular complications of chronic lung diseases, and researchers hope to use resident or circulating stem/progenitor cells to treat chronic lung diseases and their vascular complications. It is becoming more and more clear that progress in mechanobiology will help to understand the various influences of physical forces and extracellular matrix composition on the phenotype and features of the progenitor cells and stem cells. The current review provides an overview of current concepts in the field.
Details
- Title: Subtitle
- From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling
- Creators
- Rebecca L. Heise - Virginia Commonwealth UniversityPatrick A. Link - Virginia Commonwealth UniversityLaszlo Farkas - Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- Frontiers in pediatrics, Vol.4, p.80
- DOI
- 10.3389/fped.2016.00080
- PMID
- 27583245
- PMCID
- PMC4988064
- NLM abbreviation
- Front Pediatr
- ISSN
- 2296-2360
- eISSN
- 2296-2360
- Publisher
- Frontiers Media Sa
- Number of pages
- 9
- Grant note
- R21 HL123044 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R21HL123044 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 08/17/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center
- Record Identifier
- 9984948043002771
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