Journal article
From MC1R to MC5R, a new horizon for the podoprotective effect of melanocortin
Kidney international, Vol.107(5), pp.779-781
05/2025
DOI: 10.1016/j.kint.2025.01.026
PMCID: PMC13501969
PMID: 40254355
Abstract
The successful use of adrenocorticotropic hormone in treating proteinuric glomerulopathies attached new importance to the melanocortin receptors. While MC1R was originally identified as the receptor mediating melanocortins’ podoprotection, Chen et al.’s work in this issue highlights the role of MC5R in maintaining podocyte integrity in the face of stressors, by modulating glycogen synthase kinase-3 β signaling. These findings fill in a gap about melanocortin signaling in podocytes, supporting the therapeutic potential of MC5R agonism, while prompting questions for discussion.
Details
- Title: Subtitle
- From MC1R to MC5R, a new horizon for the podoprotective effect of melanocortin
- Creators
- Hua Sun - Division of Nephrology, Stead Family Department of Pediatrics, Carver College of Medicine, the University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.107(5), pp.779-781
- DOI
- 10.1016/j.kint.2025.01.026
- PMID
- 40254355
- PMCID
- PMC13501969
- NLM abbreviation
- Kidney Int
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 05/2025
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984811215602771
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