Journal article
From Protecting the Heart to Improving Athletic Performance – the Benefits of Local and Remote Ischaemic Preconditioning
Cardiovascular drugs and therapy, Vol.29(6), pp.573-588
12/01/2015
DOI: 10.1007/s10557-015-6621-6
PMCID: PMC4674524
PMID: 26477661
Abstract
Remote Ischemic Preconditioning (RIPC) is a non-invasive cardioprotective intervention that involves brief cycles of limb ischemia and reperfusion. This is typically delivered by inflating and deflating a blood pressure cuff on one or more limb(s) for several cycles, each inflation-deflation being 3–5 min in duration. RIPC has shown potential for protecting the heart and other organs from injury due to lethal ischemia and reperfusion injury, in a variety of clinical settings. The mechanisms underlying RIPC are under intense investigation but are just beginning to be deciphered. Emerging evidence suggests that RIPC has the potential to improve exercise performance, via both local and remote mechanisms. This review discusses the clinical studies that have investigated the role of RIPC in cardioprotection as well as those studying its applicability in improving athletic performance, while examining the potential mechanisms involved.
Details
- Title: Subtitle
- From Protecting the Heart to Improving Athletic Performance – the Benefits of Local and Remote Ischaemic Preconditioning
- Creators
- Vikram Sharma - University College LondonReuben Marsh - The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX UKBrian Cunniffe - English Institute of SportMarco Cardinale - Aspire AcademyDerek M. Yellon - The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX UKSean M. Davidson - The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX UK
- Resource Type
- Journal article
- Publication Details
- Cardiovascular drugs and therapy, Vol.29(6), pp.573-588
- DOI
- 10.1007/s10557-015-6621-6
- PMID
- 26477661
- PMCID
- PMC4674524
- NLM abbreviation
- Cardiovasc Drugs Ther
- ISSN
- 0920-3206
- eISSN
- 1573-7241
- Publisher
- Springer US
- Number of pages
- 16
- Language
- English
- Date published
- 12/01/2015
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806502302771
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